Memory is of fundamental importance for cognitive, social, and educational function, making it a target for neuropsychological assessment. The subject of this review is one particular type of memory, namely, episodic memory of unique events and experiences. Episodic memory allows for rapid, even one-trial learning of new information and retention of it for later retrieval. It depends on a particular neural substrate that undergoes a protracted developmental course. The review features discussion of some of the challenges associated with valid assessment of this specific form of memory in the preschool period, as well as a description and critical evaluation of available standardized measures. It also features description of two new approaches to assessment of episodic memory and their sensitivity to memory-specific deficits in the preschool years and in infancy. The review ends with introduction of the NIH Toolbox Picture Sequence Memory Test, designed as a measure of episodic memory in the preschool years and beyond.
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http://dx.doi.org/10.1007/s11065-012-9219-9 | DOI Listing |
Cell Rep
January 2025
Centre for Systems Neuroscience, University of Leicester, Leicester, UK; Hospital Del Mar Medical Research Institute (IMIM), Barcelona, Spain; Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
In subjects implanted with intracranial electrodes, we use two different stories involving the same person (or place) to evaluate whether and to what extent context modulates human single-neuron responses. Nearly all neurons (97% during encoding and 100% during recall) initially responding to a person/place do not modulate their response with context. Likewise, nearly none (<1%) of the initially non-responsive neurons show conjunctive coding, responding to particular persons/places in a particular context during the tasks.
View Article and Find Full Text PDFEndocrinol Diabetes Metab J
June 2024
Medical & Research Services, Veterans Affairs New Jersey Healthcare System, East Orange, New Jersey, USA.
Aims: Behavioral pattern separation is a hippocampal-dependent component of episodic memory and a sensitive marker of early cognitive decline. Here we tested whether mild traumatic injury causes loss of pattern separation in the rat and for its prevention by a novel neuroprotective peptide fragment of the human serotonin 2A receptor (SN..
View Article and Find Full Text PDFAppl Neuropsychol Adult
January 2025
Department of Rehabilitation Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Objective: This study evaluated the reliability and validity of the In-Out-Test for detecting episodic memory deficits in stroke patients and explored its potential as a clinical test.
Methods: A total of 75 stroke patients and 120 healthy controls underwent tests, including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Picture-Based Memory Impairment Screen (PMIS), and In-Out-Test. Reliability metrics (Cronbach's α, inter-scorer reliability, test-retest reliability), criterion validity, corrected item-total correlation, hierarchical regression analysis and ROC curve analysis were performed to determine the sensitivity and specificity of the In-Out-Test.
Sleep Health
January 2025
Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol Hospital, Prague, Czech Republic.
Study Objectives: Sleep is essential for proper function of the mind and body. Studies report the effect of sleep problems on cognition but focus on only a single or limited number of sleep indicators or on clinical populations (e.g.
View Article and Find Full Text PDFCogn Psychol
January 2025
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China; Chinese Institute for Brain Research, China. Electronic address:
Episodic memories, particularly temporal order memory, are influenced by event boundaries. Although numerous theoretical and computational models have been developed to explain this phenomenon, creating a model that can explain a wide range of behavioral data and is supported by neural evidence remains a significant challenge. This study presented a new model, grounded in ample evidence of position coding, to account for the impact of event boundaries on temporal order memory.
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