DNA-based delivery vehicles: pH-controlled disassembly and cargo release.

Chem Commun (Camb)

Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.

Published: December 2012

Non-Watson-Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508031PMC
http://dx.doi.org/10.1039/c2cc37471dDOI Listing

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