AI Article Synopsis
- Dwarf elder fruits (Sambucus ebulus) contain ebulin f, a lectin similar to the highly toxic ricin.
- Ebulin f was tested for toxicity in mice and caused specific damage to the intestines, leading to cell death (apoptosis) in the intestinal crypts.
- Compared to ricin, ebulin f was significantly less toxic, with small intestine crypts showing greater sensitivity than those in the large intestine.
Article Abstract
Dwarf elder fruits (Sambucus ebulus) contain the ribosome-inactivating lectin ebulin f structurally related to ricin. We investigated intraperitoneal toxicity of ebulin f in mice and found that it triggers specific derangement of the intestines. Ebulin f was much less toxic than ricin to mice when administered intraperitoneally. The targets were cells of the intestinal crypts, which underwent apoptosis. Small intestine crypts were more sensitive than large intestine crypts.
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| http://dx.doi.org/10.1016/j.toxicon.2012.10.009 | DOI Listing |
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