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Coding Variants of the Genitourinary Development Gene Carry High Risk for Prostate Cancer.
JCO Precis Oncol
January 2025
Medical Research Service, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN.
Purpose: Considerable genetic heterogeneity is currently thought to underlie hereditary prostate cancer (HPC). Most families meeting criteria for HPC cannot be attributed to currently known pathogenic variants.
Methods: To discover pathogenic variants predisposing to prostate cancer, we conducted a familial case-control association study using both genome-wide single-allele and identity-by-descent analytic approaches.
Temperature-Robust Solvation Enabled by Solvent Interactions for Low-Temperature Sodium Metal Batteries.
J Am Chem Soc
January 2025
School of Energy and Environment, Southeast University, Nanjing 210096, China.
The broad temperature adaptability associated with the desolvation process remains a formidable challenge for organic electrolytes in rechargeable metal batteries, especially under low-temperature (LT) conditions. Although a traditional approach involves utilizing electrolytes with a high degree of anion participation in the solvation structure, known as weakly solvation electrolytes (WSEs), the solvation structure of these electrolytes is highly susceptible to temperature fluctuations, potentially undermining their LT performance. To address this limitation, we have devised an innovative electrolyte that harnesses the interplay between solvent molecules, effectively blending strong and weak solvents while incorporating anion participation in a solvation structure that remains mostly unchanged by temperature variations.
View Article and Find Full Text PDFUse of Electronic Health Records to Identify Factors Related to Skin Changes in Terminal Patients.
Adv Skin Wound Care
January 2025
Chia-Jung Chan, MS, RN, is Head Nurse, Taipei Medical University Hospital, Taipei, Taiwan. Yeu-Hui Chuang, PhD, RN, is Professor, School of Nursing, College of Nursing, Taipei Medical University, and Researcher, Research Center in Nursing Clinical Practice, Wan Fang Hospital, Taipei Medical University; Tsai-Wei Huang, PhD, RN, is Professor, School of Nursing, College of Nursing. Taipei Medical University, and Researcher, Research Center in Nursing Clinical Practice, Wan Fang Hospital, Taipei Medical University; Made Satya Nugraha Gautama, S.Kep, Ns, is Lecturer, Department of Nursing, Faculty of Medicine, Universitas Pendidikan Ganesha, Bali, Indonesia.
Objective: To investigate the incidence of skin changes at life's end (SCALE) among hospice patients and identify associated factors.
Methods: The authors conducted a retrospective chart review of demographic data, medical history, Braden Scale assessment scores, Charlson Comorbidity Index, symptom records, and medical treatments of patients admitted to a local teaching hospital's hospice unit between May 2019 and April 2021.
Results: Most (79%) of the 300 hospice patients included in the study had cancer.
Measurement of inferior colliculus volume based on MRI image stacks and its relationship with age and hearing status.
PLoS One
January 2025
Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany.
The inferior colliculus is a key nucleus in the central auditory pathway, integrating acoustic stimuli from both cochleae and playing a crucial role in sound localization. It undergoes functional and structural development in childhood and experiences age-related degeneration later in life, contributing to the progression of age-related hearing loss. This study aims at finding out, whether the volume of the human inferior colliculus can be determined by analysis of routinely performed MRIs and whether there is any age-related variation.
View Article and Find Full Text PDFThe Neurodiversity Framework in Medicine: On the Spectrum.
Dev Neurobiol
January 2025
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA.
The term "neurodiversity" refers to the natural heterogeneity in human neurological functioning, which includes neurodevelopmental differences and other mental health conditions (e.g., autism spectrum disorder [ASD], attention-deficit hyperactivity disorder [ADHD], dyslexia, bipolar disorder, schizophrenia, and depression).
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