AI Article Synopsis
- The study aimed to determine if there was a difference in HIV prevalence between women who opted in and those who opted out of a voluntary counseling and testing study in South Africa.
- Data was collected through anonymous dried blood samples from 7,238 women, out of which 1,041 had unknown HIV status, and 343 agreed to participate.
- The findings showed comparable HIV seroprevalence rates of 13.3% for all eligible women and 13.1% for those who enrolled, suggesting participation didn’t significantly affect HIV status representation.
Article Abstract
Objective: To assess whether there was a difference in HIV seroprevalence between eligible women who declined and those who agreed to participate in a study of voluntary counseling and testing among women entering labor with unknown HIV status in South Africa.
Methods: Anonymous cord blood specimens were collected-as dried blood spots-from all women approached for participation in a cluster-randomized trial. No patient identifiers were included on the cord blood specimens. The dried blood spots were analyzed for HIV antibody via enzyme immunoassay and western blotting.
Results: Of 7238 women screened for study participation, 1041 (14.4%) had undocumented HIV status; of these women, 542 were eligible for inclusion and 343 enrolled. Based on 513 evaluable samples, the overall seroprevalence was 13.3% (95% confidence interval [CI], 10.4-16.5), which was similar to the 13.1% (95% CI, 9.7-17.2) seroprevalence among the 343 enrolled women.
Conclusion: Seroprevalence among eligible women was similar to that among enrolled women, which indicates that study participation did not select for a group with an HIV seroprevalence substantially different from that among women who declined to enroll.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553312 | PMC |
| http://dx.doi.org/10.1016/j.ijgo.2012.07.029 | DOI Listing |
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