The past two decades have witnessed dramatic advances in palliative and end-of-life care research with increased understanding of the burden of life-limiting diseases on patients, families, clinicians, and our healthcare system; and researchers have documented palliative care interventions that improve patient and family outcomes and reduce the costs of care (Detering, Hancock, Reade, & Silvester, 2010). These advances have led to a new era of palliative and end-of-life care research and practice with widespread recognition of its accomplishments and successes. Consequently, we now have an important opportunity to reassess our recent successes and challenges and to identify the goals and benchmarks that will ensure ongoing robust advances in this now-recognized and critical scientific area. High-quality palliative and end-of-life care will be best informed by methodologically strong research efforts that generate a body of evidence with the capacity to support and direct care and effect changes in practice. It is in this context that the National Institute of Nursing Research conceptualized and led a Summit titled The Science of Compassion: Future Directions in End-of-Life and Palliative Care Research in August, 2011. In this summary article, we present brief overviews of the six articles chosen for this Special Issue of Nursing Outlook, examine their key conclusions, articulate gaps and needs, and discuss next steps in palliative and end-of-life care research through the lens of these six topics.
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http://dx.doi.org/10.1016/j.outlook.2012.08.006 | DOI Listing |
Alzheimers Dement
December 2024
Ambridgeshire and Peterborough NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom.
Background: People with dementia frequently develop behavioural and psychological symptoms, sometimes necessitating care in specialist dementia mental health wards. There has been little research on their life expectancy following admission or need for palliative care. The work presented here explores the mortality of these patients and whether this can be predicted at their time of admission to the ward.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
College of Nursing and Mo-Im Kim Nursing Research Institute, Yonsei University, Seoul, South Korea.
Aim: Digital health interventions, including health analytics, telehealth, mHealth and digitised healthcare systems, are rapidly advancing and demonstrate effectiveness in palliative care. Although end-of-life (EOL) and hospice care are within palliative care, they differ in outcomes, target populations and delivery systems. This review examines research trends to guide digital health strategies for EOL and hospice care.
View Article and Find Full Text PDFDrug Dev Res
February 2025
Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a neurodegenerative pathology caused by accumulation of mutant neuroserpin (NS) polymers inside the endoplasmic reticulum (ER) of neurons, leading to cellular toxicity and neuronal death. To date, there is no cure for FENIB, and only palliative care is available for FENIB patients, underlining the urgency to develop therapeutic strategies. The purpose of this work was to create a cellular system designed for testing small molecules able to reduce the formation of NS polymers.
View Article and Find Full Text PDFDan Med J
November 2024
Department of Emergency Medicine and Trauma Care, Aalborg University Hospital.
Introduction: Among all Danish dying patients, 80% rely on non-specialised palliative care, an area lacking national and international guidelines. In this pilot study, we developed and tested an acute basic palliation concept (ABPC), a structured end-of-life (EOL) care plan for patients discharged from the emergency department to die at home compared with standard care.
Methods: This study compared symptom scores and EOL care statement scores during a standard care period with an ABPC period using unvalidated questionnaires.
Dan Med J
November 2024
Department of Gastrointestinal Surgery, Aarhus University Hospital.
Introduction: Refractory malignant ascites (RMA) is a manifestation of end-stage cancer disease with a major impact on quality of life due to the symptom burden and need for repeated hospitalisations. We previously described the implantation of the permanent PleurX catheter as a treatment of RMA. The present study aimed to evaluate and describe our experience with the permanent PleurX catheter system in the largest cohort to date.
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