Objective: To evaluate the safety and efficacy of modified Prolift pelvic floor reconstruction with improving the placement of Prolift-A in treatment of severe pelvic floor dysfunction and stress urinary incontinence (SUI).
Methods: From July 2008 to September 2010, 170 cases with severe pelvic organ prolapse (POP) treated by modified Prolift pelvic floor reconstruction surgery in Fuzhou General Hospital were enrolled in this study. The Prolift-A was laid tension-free under the mid-urethra with the position of Prolift-A displaced from the neck of bladder to the mid-urethra. No concomitant tension-free urethra suspender via vagina was performed. Primary outcomes were assessed with POP quantitation (POP-Q) system to evaluate the postoperative anatomical replacement stage. Secondary outcome measure were: urogenital distress inventory 6 (UDI-6), the incontinence impact questionnaire 7 (IIQ-7) and the pelvic floor incontinence questionnaire 7 (PFIQ-7) to evaluate the impact on life quality at the follow-up of 1, 6, 12 months.
Results: At 6 and 12 months after surgery, 168 cases and 163 cases were followed up. The anatomical cure rates were 98.8% (166/168) at 6 months and 97.5% (159/163) at 12 months, respectively. One case with bladder injury and 1 case with rectum injury were observed. Five cases with recurrence were observed, including 2 cases with anterior vagina prolapse, 2 cases with uterine prolapse and 1 case with posterior vagina prolapse. Meanwhile, 3 cases with hematoma and 7 cases with mesh erosion were observed. Quality of life of all patients were improved significantly by UDI-6, IIQ-7 and PFIQ-7 scoring system evaluation. Among 79 POP patients with SUI, the cure rate of SUI was 93.7% (74/79). Of 5 cases with symptomatic SUI, 2 cases were needed surgical intervention. Twenty-three cases were found with minimal SUI symptoms and subjective satisfaction without objective influence on quality of life. Seven patients presented dysuria after surgery, 5 cases recovered urination with 10 days, 1 case recovered with 1 months, and 1 case with 6 months by bladder drainage. Eleven cases with discomfort urination and 3 cases with slow urination were found.
Conclusions: The modified Prolift pelvic reconstructive surgery was safe and efficacy intervention in treatment of POP and prevention of SUI.
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Therap Adv Gastroenterol
January 2025
Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, 510655, Guangzhou, Guangdong, China.
Background: Limited research exists on colorectal cancer (CRC) patients with bladder invasion, with survival outcomes post-cystectomy underexplored and a debate between partial and total cystectomy ongoing.
Objective: The study aimed to evaluate the effect of pathological bladder invasion on the long-term tumour prognosis of patients with clinically diagnosed bladder invasion in CRC after cystectomy.
Design: Retrospective, cohort study.
Afr J Reprod Health
November 2024
Meng Research Institute, Changzhou Hospital of Traditional Chinese Medicine, Chang Zhou 213003, Jiangsu, China.
This was an original article, and mainly evaluated the impacts of Buzhong Yiqi decoction and biofeedback electrical stimulation on pelvic floor muscle strength and the quality of life in patients with postpartum stress urinary incontinence (PSUI). PSUI patients (total = 256) were randomly selected into a control group and study group. The control group adopted pelvic floor muscle rehabilitation training only while the study group added Buzhong Yiqi decoction and biofeedback electrical stimulation.
View Article and Find Full Text PDFAfr J Reprod Health
November 2024
Department of Obstetrics and Gynecology, Binhai County People's Hospital, The Affiliated Hospital of Kangda College of Nanjing Medical University, Yancheng 224500, Jiangsu, China.
This was an original article, and the objective of this study was to clarify the short-term effects of analgesic delivery on the pelvic floor function of primiparous women. Three hundred primiparas who delivered vaginally in The Affiliated Hospital of Kangda College of Nanjing Medical University from January 2022 to July 2022 were enrolled, and were divided into control and intervention groups. The control accepted traditional delivery without special analgesic intervention, while the intervention group accepted intraspinal block analgesia at the time of delivery.
View Article and Find Full Text PDFClin Transl Med
January 2025
Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need for new treatment strategies.
Methods: Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T cell coculture, crystal violetstaining, ELISA, metabonomic and clinical tumour samples were conducted to assess the role of EDEM3 in immune escape and itsmolecular mechanisms.
Tech Coloproctol
January 2025
Surgical Department, Ostomy and Pelvic Floor Rehabilitation Center, Azienda Sanitaria Universitaria Friuli Centrale, Santa Maria della Misericordia, Udine, Italy.
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