AI Article Synopsis
- - The study investigates the potential link between human papillomavirus (HPV) and lung cancer by analyzing 100 patients from Italy and the UK.
- - Researchers checked for HPV DNA in both tumor and non-tumor lung samples using specific methods, but found no evidence of HPV in any of the specimens.
- - The findings suggest that HPV is not a risk factor for lung cancer in the studied populations, contributing to better understanding of lung cancer risks associated with other factors.
Article Abstract
Background: Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear.
Methods: We examined a series of 100 lung cancer patients from Italy and the UK for the presence of HPV DNA in both lung tumor specimens and adjacent non-tumoral specimens from the same patients. Thirty-five of the most clinically relevant HPV types were assayed using PCR amplification of the highly conserved L1 region of the viral genome followed by hybridization with specific probes.
Results: No HPV was detected in tumor specimens nor in normal lung tissue of any patient.
Conclusions: These data indicate that, in this Western series, HPV is not associated with the risk of lung cancer. Our findings will help refine estimates of lung cancer risk in patients affected by a common viral infection involved in other types of human cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537645 | PMC |
| http://dx.doi.org/10.1186/1471-2407-12-512 | DOI Listing |
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