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Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301).
Sci Rep
January 2025
Department of Medical Oncology, Sasebo Kyosai Hospital, Sasebo, Japan.
The relationship between nanoliposomal irinotecan/fluorouracil/leucovorin (NFF) treatment outcomes and neutropenia in patients with pancreatic cancer has not been thoroughly examined. Thus, we conducted a retrospective analysis of data from patients with pancreatic cancer who were treated with NFF to investigate this relationship. Neutropenia was assessed according to the Common Terminology Criteria for Adverse Events across three cutoffs: A (grade 0 versus grade 1-4), B (grades 0-1 versus 2-4), and C (grades 0-2 versus 3-4).
View Article and Find Full Text PDFAssessing Aflatoxin Exposure in the United Arab Emirates (UAE): Biomonitoring AFM1 levels in Urine Samples and their Association with Dietary Habits.
Environ Toxicol Pharmacol
January 2025
Environmental Health Sciences, College of Health Sciences, University of Sharjah, United Arab Emirates (UAE); Sharjah Institute for Medical Research, University of Sharjah, UAE; Research Institute of Sciences and Engineering, University of Sharjah, UAE; Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland. Electronic address:
Background: Aflatoxins, known for their carcinoginc properties and produced by Aspergillus fungi, pose a substantial threat to public health, particularly in regions with hot and humid climates, where individuals are exposed to these toxins through contaminated food. The primary objective of this study was to assess the extent of aflatoxin exposure in the Emirate of Sharjah employing Aflatoxin M1 (AFM1) as a biomarker in urine samples from adult participants. Furthermore, this study aimed to explore the relationship between dietary habits and AFM1 levels in order to establish a potential link.
View Article and Find Full Text PDFAssessment of cold resistance in tobacco varieties using JIP-test parameters and seedling growth.
Physiol Plant
January 2025
College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou, China.
Cold stress (CS) is a significant natural hazard, and distinguishing between plant cold resistance and sensitivity is critical for cultivar breeding and the development of germplasm resources. This study used 205 tobacco (Nicotiana tabacum L.) varieties from around the world to investigate the changes in the chlorophyll a fluorescence (OJIP) transients, JIP-test parameters, and seedling growth caused by seven days of CS (5°C) treatment.
View Article and Find Full Text PDFAn integrative review on the risk factors, prevention, and control strategies for carbapenem-resistant colonization in critically ill patients.
Front Microbiol
January 2025
Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, China.
The presence of carbapenem-resistant (CR) has become one of the leading causes of life-threatening, hospital-acquired infections globally, especially with a notable prevalence in intensive care units (ICUs). The cross-transmission of microorganisms between patients and the hospital setting is crucial in the development of CR colonization and subsequent infections. Recent studies indicate that colonization typically precedes infection, suggesting the effectiveness and necessity of preventing CR colonization as a primary method to lower infection risks.
View Article and Find Full Text PDFDietary intakes of flavonoids in relation to cognitive function among middle-aged and older adults: results from the Chinese Square Dance Cohort.
Food Funct
January 2025
Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
: The study aims to explore the association between intake of dietary flavonoids and global cognition, domain-specific cognition and mild cognitive impairment (MCI) in middle-aged and older adults in China. : A cross-sectional study. : This study used baseline data collected during 2021-2023 from the Chinese Square Dance Cohort.
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