Purpose: To explore whether orthodontic light force with self-ligating brackets can reduce the amount of external apical root resorption (EARR).
Methods: Thirty patients with Class I or II crowding malocclusion were selected. Four first premolars of all patients were extracted in orthodontic treatment. 15 patients were treated with self-ligating brackets (Damon 3MX) and 15 patients with conventional ligation brackets, respectively. Patients in two groups were comparable in gender, age, crowded degree and malocclusion classification at the commencement of treatment. EARR of the maxillary and mandible incisors was evaluated on panoramic radiographs and models taken before and after treatment, and measured in millimeters. Student's t test was performed using SPSS19.0 software package.
Results: Overall, no difference was found in the amount of EARR between the two groups. The amount of EARR in maxillary central incisor was (2.05±1.51) mm in Damon group and (2.08±1.21) mm in conventional group(P=0.973>0.05); (1.77±1.01) mm in maxillary lateral incisor in Damon group and (1.91±1.59) mm in conventional group(P=0.848>0.05); (2.06±1.62) mm in mandibular central incisor in Damon group and (1.98±1.50) mm in conventional group(P=0.926>0.05); (1.94±1.45) mm in mandibular lateral incisor in Damon group and (1.84±1.17) mm in conventional group(P=0.888>0.05).
Conclusion: No difference should be expected for root resorption between self-ligating and conventional brackets in orthodontic extraction treatment.
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Am J Gastroenterol
January 2025
Queen Mary University London, London, United Kingdom.
Introduction: The London classification provides standardization for characterization of disorders of anorectal function, although prevalences and clinical impact of these disorders are unclear.
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Nat Commun
January 2025
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Biofilms are ubiquitous surface-associated bacterial communities embedded in an extracellular matrix. It is commonly assumed that biofilm cells are glued together by the matrix; however, how the specific biochemistry of matrix components affects the cell-matrix interactions and how these interactions vary during biofilm growth remain unclear. Here, we investigate cell-matrix interactions in Vibrio cholerae, the causative agent of cholera.
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Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US.
Introduction/aims: Skeletal muscle magnetic resonance imaging (MRI) is a validated noninvasive tool to assess Duchenne muscular dystrophy (DMD) progression. There is interest in finding DMD biomarkers that decrease the burden of clinical trial participation, such as wearable devices. Our aim was to evaluate the relationship between activity, via accelerometry, and skeletal muscle MRI, particularly T mapping.
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December 2024
Program for Advanced Musculoskeletal Imaging, Cleveland Clinic, Cleveland, OH, USA.
Background: Dixon-based magnetic resonance imaging (MRI) intramuscular proton density fat fraction (PDFF) is a potentially useful imaging biomarker of muscle quality. However, multi-vendor, multi-site reproducibility of intramuscular PDFF quantification, required for large clinical studies, can be strongly dependent on acquisition and processing. The purpose of this study was (I) to develop a 6-point Dixon MRI-based acquisition and processing technique for reproducible multi-vendor, multi-site quantification of thigh intramuscular PDFF; and (II) to evaluate the ability of the technique to detect differences in thigh muscle status between operated .
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Enzyme-mediated modifications of tRNA, such as 5-methylcytosine (m5C) installed by nuclear-enriched NOP2/Sun RNA methyltransferase 2 (NSUN2), play a critical role in neuronal development and function. However, our understanding of these modifications' spatial installation and biological functions remains incomplete. In this study, we demonstrate that a nucleoplasm-localized G679R NSUN2 mutant, linked to intellectual disability, diminishes NSUN2-mediated tRNA m5C in human cell lines and Drosophila.
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