[Meta analysis of association between TNF-α-308 polymorphism and periodontitis in Chinese Han population].

Purpose: To assess the association between TNF-α-308 polymorphism and periodontitis in Chinese Han population.

Methods: Articles published between 1994 and 2011 were searched in the fulltext database of CNKI, Chinese Biomedical Literature Database, Wanfang Database and PubMed. Case-control studies on TNF-α-308 polymorphism and periodontitis were searched up to Feb.,2011, including articles in Chinese and in English. Meta analysis was performed to evaluate the prevalence of Allele 2 between case group and control group.

Results: Five studies were entered into Meta analysis,with 494 cases and 501 controls . No significant heterogeneity was found among the studies(P=0.38); the pooled OR value of allele 2 was 2.12(95% CI 1.57-2.86), with significant difference(P<0.01).

Conclusion: Meta analysis showed that TNF-α-308 polymorphism was associated with periodontitis in Chinese Han population.