Purpose: To investigate the expression of activating receptor NKG2D(natural killer group 2,member D) on peripheral blood mononuclear cells(PBMCs) in patients with oral squamous cell carcinoma(OSCC) and its clinicopathological significance.
Methods: The expression of NKG2D on PBMCs in 54 OSCC patients and 20 healthy controls were assessed by flow cytometry. The data was analyzed with SPSS16.0 software package for independent-sample t test and one-way ANOVA test.
Results: The positive rate of assay for NKG2D on PBMCs in OSCC patients (12.49±5.26)% was lower than that of the controls (22.93±8.14)% (P<0.05). And which was significantly different among different clinicopathological parameters such as tumor size and disease stage(P<0.05), but no significant difference was found among different gender, age, tumor location, tumor differentiation and cervical lymph node status (P>0.05).
Conclusions: The NKG2D expression on PBMCs in OSCC patients was lower than that of healthy controls and was correlated with tumor size and disease stage.
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