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Proteasome inhibition induces microtubule-dependent changes in nuclear morphology.
iScience
January 2025
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA.
Cancers and neurodegenerative disorders are associated with both disrupted proteostasis and altered nuclear morphology. Determining if changes in nuclear morphology contribute to pathology requires an understanding of the underlying mechanisms, which are difficult to elucidate in cells where pleiotropic effects of altering proteostasis might indirectly influence nuclear morphology. To investigate direct effects, we studied nuclei assembled in egg extract where potentially confounding effects of transcription, translation, cell cycle progression, and actin dynamics are absent.
View Article and Find Full Text PDFEcthyma amidst the global monkeypox outbreak: A key differential? -A case series.
IDCases
December 2024
Department of Medicine, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Background: Ecthyma is a deeper form of impetigo involving the epidermis and dermis causing ulcerative plaques. Pathogens commonly responsible for the disease (group A beta-hemolytic streptococcus and Staphylococcus aureus) typically afflicts children, presenting during early stages with skin lesions that can closely resemble other vesicular and ulcerative dermatoses, such as those observed in mpox infection. The ongoing global outbreak of monkeypox has escalated the urgency for clinicians to accurately differentiate between these conditions due to their overlapping dermatological manifestations.
View Article and Find Full Text PDFSevere dual fungal infection after bispecific antibody therapy: A case of invasive aspergillosis and mucormycosis in immunocompromised patient.
IDCases
December 2024
Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Laboratory of Hematology, University of Liège, Liège, Belgium.
Bispecific antibody is a new treatment for hematological disease, especially for lymphoma, myeloma and acute lymphoblastic leukemia. This class of treatment presents the same kind of side effect as CAR-T cell which are immune-mediated. Nevertheless, infectious complication remains a major concerns with related mortality.
View Article and Find Full Text PDFResponse to "Predictors of Kidney Recovery in Acute Interstitial Nephritis".
Kidney Int Rep
January 2025
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Effect of Transplanted Liver Fat Percentage on Organ Survival: A Retrospective Review.
Exp Clin Transplant
December 2024
>From the Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: Liver transplant is the most effective therapeutic option for patients with end-stage liver disease, nonalcoholic steatohepatitis, and acute liver failure. We evaluated whether the percentage of hepatic fat percentage affected transplant outcomes to determine whether livers with varying severity of macrosteatosis should be considered suitable for donation.
Materials And Methods: We analyzed data from 381 patients with liver failure who received liver transplant at Montaseriyeh Hospital in Mashhad, Iran, between 2013 and 2022.
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