Background: Carcinoma of breast is a leading cause of death in women throughout the world. Difficulty in diagnosis occurs in routine Hematoxylin and Eosin (H&E) stained sections to differentiate premalignant lesions like epitheliosis and malignant lesions like carcinoma in situ which may affect prognosis.
Aims: Our study was done to assess the role of proliferative markers in this field.
Materials And Methods: In this study, total 66 cases of different breast lesions were studied by H&E stained sections as well as proliferative markers like silver staining nucleolar organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA).
Results: Statistically significant differences found in expression of proliferative markers between most of them.
Conclusion: Study of proliferative markers help in the proper diagnosis of different breast lesions which lies in the grey zone on routine histopathology.
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| http://dx.doi.org/10.1007/s12262-010-0010-y | DOI Listing |
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