AI Article Synopsis
- - The study investigates the relationship between the ratio of the lengths of the second and fourth fingers (2D:4D) and androgen receptor (AR) gene polymorphisms in Chinese individuals, noting that previous research showed a connection to prenatal androgen levels in both humans and mice.
- - Measurements were taken from photocopies and actual finger measurements to analyze the 2D:4D ratios and genotyping for AR polymorphisms was performed using DNA analysis techniques.
- - Results indicated that the left hand showed a longer 2D:4D ratio compared to the right hand for both genders, but no association was found between CAG/GGN genetic variations and the 2D:4D ratios in any of the hand
Article Abstract
Objectives: The relative length of the second-to-fourth digits (2D:4D) has been linked with prenatal androgen in humans. A recent study shows that the 2D:4D ratio in mice is controlled by the balance of androgen to estrogen signaling during a narrow window of digit development. Androgen receptor (AR) activity is higher in digit 4 than in digit 2, and inactivation of AR decreases growth of digit 4, which causes a higher 2D:4D ratio. At the molecular level, the effect of androgens is mediated through the activation of AR. The CAG/GGN repeat polymorphisms of the AR gene are associated with AR activity. Here, we investigate the effect of CAG/GGN repeat polymorphisms in AR on 2D:4D in Chinese.
Methods: Digit lengths of the second and fourth fingers were measured from photocopies of the ventral surface of the hand and by actual finger measurements. We genotyped AR polymorphisms by ABI 3730 DNA analyzer.
Results: We found that left hand 2D:4D ratio was longer than that of the right hand both in males and in females. We failed to find any relationship between CAG / GGN alleles and the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios (all, r < 0.20, P > 0.05).
Conclusions: In this study, we first found that the left hand 2D:4D ratio was longer than that of the right hand in both males and females. However, we found that both CAG and GGN alleles were not associated with the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios.
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| http://dx.doi.org/10.1002/ajhb.22347 | DOI Listing |
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