AI Article Synopsis
- Dopamine transmission is essential for exploratory behavior, and its regulation involves acetylcholine from the forebrain and brainstem.
- Mice without forebrain acetylcholine show increased striatal dopamine release and become hyperactive, while those lacking brainstem acetylcholine are less active.
- Removing both sources of acetylcholine normalizes activity levels, suggesting that these cholinergic systems work together to manage dopamine signaling and motor behavior.
Article Abstract
Dopamine transmission is critical for exploratory motor behaviour. A key regulator is acetylcholine; forebrain acetylcholine regulates striatal dopamine release, whereas brainstem cholinergic inputs regulate the transition of dopamine neurons from tonic to burst firing modes. How these sources of cholinergic activity combine to control dopamine efflux and exploratory motor behaviour is unclear. Here we show that mice lacking total forebrain acetylcholine exhibit enhanced frequency-dependent striatal dopamine release and are hyperactive in a novel environment, whereas mice lacking rostral brainstem acetylcholine are hypoactive. Exploratory motor behaviour is normalized by the removal of both cholinergic sources. Involvement of dopamine in the exploratory motor phenotypes observed in these mutants is indicated by their altered sensitivity to the dopamine D2 receptor antagonist raclopride. These results support a model in which forebrain and brainstem cholinergic systems act in tandem to regulate striatal dopamine signalling for proper control of motor activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336695 | PMC |
| http://dx.doi.org/10.1038/ncomms2144 | DOI Listing |
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