In this paper I will discuss clinical material and make some hypotheses on how to work with patients for whom trans-generational transmission of trauma is an issue. Basing my hypothesis on two clinical cases, I will propose a way of dealing with undigested facts, the fabric of trauma, which generate deadly ghosts and mental voids that are transmitted from one generation to the next. I will propose a way of formulating interpretations for the unthinkable to become thinkable and find a representation in the mind of patients who suffer from transgenerationally transmitted trauma. Some thoughts will be given to the maternal and the paternal transmitters of trauma in relation to child development issues.
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http://dx.doi.org/10.1111/j.1468-5922.2012.02005.x | DOI Listing |
Microbiol Spectr
July 2024
Pathogen Genomics Laboratory, Bioscience Program, Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Unlabelled: A hallmark of cerebral malaria (CM) is sequestration of -infected erythrocytes (IE) within the brain microvasculature. Binding of IE to endothelium reduces microvascular flow and, combined with an inflammatory response, perturbs endothelial barrier function, resulting in breakdown of the blood-brain barrier (BBB). Cytoadherence leads to activation of the endothelium and alters a range of cell processes affecting signaling pathways, receptor expression, coagulation, and disruption of BBB integrity.
View Article and Find Full Text PDFFront Immunol
June 2022
Department of Biological Sciences, Sunway University, Petaling Jaya, Malaysia.
In parallel to the uncontrolled use of antibiotics, the emergence of multidrug-resistant bacteria, like , has posed a severe threat. predominates in the nosocomial setting due to its ability to persist in hospitals and survive antibiotic treatment, thereby eventually leading to an increasing prevalence and mortality due to its infection. With the increasing spectra of drug resistance and the incessant collapse of newly discovered antibiotics, new therapeutic countermeasures have been in high demand.
View Article and Find Full Text PDFAm J Disaster Med
January 2021
Department of Emergency Medicine, Johns Hopkins University, Baltimore, Maryland.
J Proteomics
March 2021
Chemical Sciences Division, Hollings Marine Laboratory, National Institute of Standards and Technology, 331 Fort Johnson Road, Charleston, SC 29412, USA. Electronic address:
Using high-throughput BioPlex assays, we determined that six fractions from the venom of Conus nux inhibit the adhesion of various recombinant PfEMP-1 protein domains (PF08_0106 CIDR1α3.1, PF11_0521 DBL2β3, and PFL0030c DBL3X and DBL5e) to their corresponding receptors (CD36, ICAM-1, and CSA, respectively). The protein domain-receptor interactions permit P.
View Article and Find Full Text PDFElife
December 2020
Malaria Biochemistry Laboratory, The Francis Crick Institute, London, United Kingdom.
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane seals and pinches off behind the parasite through an unknown mechanism, enclosing the parasite within the RBC. During invasion, several parasite surface proteins are shed by a membrane-bound protease called SUB2.
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