We investigated the near-field enhancement of a localized surface plasmon resonance (LSPR) structure based on gold nanograting pairs with a nanosized gap. The results calculated by finite-difference time-domain and rigorous coupled-wave analysis methods presented that the nanogap enclosed by two neighboring nanogratings produced significant confinement and enhancement of electromagnetic fields and allowed a sensitive detection in sensing of surface binding events. Gold gratings with a narrow gap distance less than 10 nm showed enhanced refractive index sensitivity due to the intensified optical field at the nanogap, outperforming the LSPR structure with noninteracting nanogratings. Also, we analyzed the effectiveness of using an overlap integral (OI) between analyte and local plasmon field to estimate the detection sensitivity. We found a strong correlation of field-analyte OI with far-field sensor sensitivity.
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http://dx.doi.org/10.1364/AO.51.007437 | DOI Listing |
Alzheimers Res Ther
January 2025
Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, Turin, 10126, Italy.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with both genetic and environmental factors contributing to its pathogenesis. While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. This study investigates a large Italian family with late-onset autosomal dominant AD, identifying a novel rare missense variant in GRIN2C gene associated with the disease, and evaluates the functional impact of this variant.
View Article and Find Full Text PDFCancer Imaging
January 2025
Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Background: Current diagnostic imaging modalities have limited ability to differentiate between malignant and benign pancreaticobiliary disease, and lack accuracy in detecting lymph node metastases. F-Prostate-Specific Membrane Antigen (PSMA) PET/CT is an imaging modality used for staging of prostate cancer, but has incidentally also identified PSMA-avid pancreatic lesions, histologically characterized as pancreatic ductal adenocarcinoma (PDAC). This phase I/II study aimed to assess the feasibility of F-PSMA PET/CT to detect PDAC.
View Article and Find Full Text PDFSci Data
January 2025
University of Southern California, Viterbi School of Engineering, 3737 Watt Way, Powell Hall of Engineering, Los Angeles, CA, 90089, USA.
Soil erosion in North Africa modulates agricultural and urban developments as well as the impacts of flash floods. Existing investigations and associated datasets are mainly performed in localized urban areas, often representing a limited part of a watershed. The above compromises the implementation of mitigation measures for this vast area under accentuating extremes and continuous hydroclimatic fluctuations.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Nuclear, Plasma, and Radiological Engineering, The Grainger College of Engineering, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Doped semiconductors can exhibit metallic-like properties ranging from superconductivity to tunable localized surface plasmon resonances. Diamond is a wide-bandgap semiconductor that is rendered electronically active by incorporating a hole dopant, boron. While the effects of boron doping on the electronic band structure of diamond are well-studied, any link between charge carriers and plasmons has never been shown.
View Article and Find Full Text PDFComput Biol Med
January 2025
Department of Biomedical Engineering, Faculty of Science and Engineering, Swansea University, Swansea, United Kingdom; Zienkiewicz Institute for Modelling Data and AI, Swansea University, Swansea, United Kingdom. Electronic address:
Most cell types are mechanosensitive, their activities such as differentiation, proliferation and apoptosis, can be influenced by the mechanical environment through mechanical stimulation. In three dimensional (3D) mechanobiological in vitro studies, the porous structure of scaffold controls the local mechanical environment that applied to cells. Many previous studies have focused on the topological design of homogeneous scaffold struts.
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