A novel method for modeling the neutron time of flight (nTOF) detector response in current mode for inertial confinement fusion experiments has been applied to the on-axis nTOF detectors located in the basement of the Z-Facility. It will be shown that this method can identify sources of neutron scattering, and is useful for predicting detector responses in future experimental configurations, and for identifying potential sources of neutron scattering when experimental set-ups change. This method can also provide insight on how much broadening neutron scattering contributes to the primary signals, which is then subtracted from them. Detector time responses are deconvolved from the signals, allowing a transformation from dN/dt to dN/dE, extracting neutron spectra at each detector location; these spectra are proportional to the absolute yield.
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http://dx.doi.org/10.1063/1.4742140 | DOI Listing |
J Colloid Interface Sci
December 2024
School of Health Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Hypothesis: Nanoscale characterisation of the self-associated species formed by amphiphilic pharmaceuticals in aqueous solution carries relevance across their entire journey from development through to manufacture - relevant, therefore, not only as regards formulation of the drug products as medicines, but also potentially relevant to their bioavailability, activity, and clinical side effects. Such knowledge and understanding, however, can only be fully secured by applying a range of experimental and theoretical methodologies.
Experiments: Herein, we apply a synergistic combination of solubility, surface tension, SANS, NMR and UV spectroscopic studies, together with MD simulation and QM calculations, to investigate the meso-structures of propranolol hydrochloride aggregates in bulk aqueous solutions, at concentrations spanning 2.
Nanotechnology
December 2024
CCTS/DFQM, UFSCar - Campus Sorocaba, Rod. João Leme dos Santos km 110 - SP-264 Bairro do Itinga - Sorocaba CEP 18052-780, Sorocaba, 18052-780, BRAZIL.
Nanomaterials stand out for their exceptional properties and innovative potential, especially in applications that protect against space radiation. They offer an innovative approach to this challenge, demonstrating notable properties of radiation absorption and scattering, as well as flexibility and lightness for the development of protective clothing and equipment. This review details the use of polymeric materials, such as polyimides (PIs), which are efficient at attenuating ultraviolet (UV) radiation and atomic oxygen (AO).
View Article and Find Full Text PDFNano Lett
December 2024
Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Interparticle ligand exchange can occur during the formation of nanoparticle superlattices (NPSLs), affecting the symmetry of the NPSLs. Here, we report time-resolved small-angle neutron scattering (TR-SANS) measurements of the interparticle exchange kinetics of thiolate ligands among gold nanoparticles (AuNPs) at different temperatures. To track the ligand exchange among AuNPs, two groups of AuNPs were functionalized with hydrogenated and deuterated dodecanethiol, respectively, and then mixed in a solvent mixture of toluene and deuterated toluene for shell contrast.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Department of Medicinal Chemistry, Uppsala University, P.O. Box 547, 751 23, Uppsala, Sweden. Electronic address:
We have investigated the effect of length and chemical structure of phospholipid tails on the spontaneous formation of unilamellar liposomal vesicles in binary solute mixtures of cationic drug surfactant and zwitterionic phosphatidylcholine phospholipids. Binary drug surfactant-phospholipid mixtures with four different phospholipids with identical headgroups (two saturated phospholipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, 14:0) and 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, 16:0), and two unsaturated lipids 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC, 18:1) and 1,2-Dierucoyl-sn-Glycero-3-Phosphatidylcholine (DEPC, 22:1)) combined with two different tricyclic antidepressant drugs (amitriptyline hydrochloride (AMT) and doxepin hydrochloride (DXP)) have been investigated with small-angle neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM). We observe a conspicuous impact of phospholipid tail structure on both micelle-to-vesicle transition point and vesicle size.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Industrial and Materials Science, Division of Engineering Materials, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.
Simultaneous rheological, polarized light imaging, and small-angle X-ray scattering experiments (Rheo-PLI-SAXS) are developed, thereby providing unprecedented level of insight into the multiscale orientation of hierarchical systems in simple shear. Notably, it is observed that mesoscale alignment in the flow direction does not develop simultaneously across nano-micro lengthscales in sheared suspensions of rod-like chiral-nematic (meso) phase forming cellulose nanocrystals. Rather, with increasing shear rate, orientation is observed first at mesoscale and then extends to the nanoscale, with influencing factors being the aggregation state of the hierarchy and concentration.
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