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The Impact of an Orofacial Muscle Strengthening Program on Temporomandibular Muscles and on the Performance of Wind Instrumentalists.
J Oral Rehabil
January 2025
Coimbra Health School, Polytechnic University of Coimbra, Coimbra, Portugal.
Introduction: Playing a wind instrument is one of the most complex tasks for the musculoskeletal system.
Objective: Verify the effectiveness of a strengthening exercise programme on musical performance and the strength of the temporomandibular muscles.
Methods: The sample was 60 participants (36 men; 24 women), with a mean age of 24.
Exploring the Therapeutic Role of Flavonoids Through AMPK Activation in Metabolic Syndrome: A Narrative Review.
Phytother Res
January 2025
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam, India.
Metabolic syndrome (MetS) is a cluster of interrelated metabolic abnormalities that significantly elevate the risk of cardiovascular disease, obesity, and diabetes. Flavonoids, a diverse class of bioactive polyphenolic compounds found in plant-derived foods and beverages, have garnered increasing attention as potential therapeutic agents for improving metabolic health. This review provides a comprehensive analysis of the therapeutic effects of flavonoids in the context of the MetS, with a particular focus on their modulation of the AMP-activated protein kinase (AMPK) pathway.
View Article and Find Full Text PDFSocioeconomic status correlates with COVID-19 vaccination coverage among primary and secondary students in the most populated city of Chile.
Sci Rep
January 2025
Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile.
The burden of COVID-19 was heterogeneous, indicating that the effects of this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), highlighting its syndemic character. While the appearance of vaccines moderated the pandemic effects, their coverage was heterogeneous too, both when comparing different countries, and when comparing different populations within countries. Of note, once again SES appears to be a correlated factor.
View Article and Find Full Text PDFpmiRScan: a LightGBM based method for prediction of animal pre-miRNAs.
Funct Integr Genomics
January 2025
Computational Structural Biology Lab, Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
MicroRNAs (miRNA) are categorized as short endogenous non-coding RNAs, which have a significant role in post-transcriptional gene regulation. Identifying new animal precursor miRNA (pre-miRNA) and miRNA is crucial to understand the role of miRNAs in various biological processes including the development of diseases. The present study focuses on the development of a Light Gradient Boost (LGB) based method for the classification of animal pre-miRNAs using various sequence and secondary structural features.
View Article and Find Full Text PDFA dataset and benchmark for hospital course summarization with adapted large language models.
J Am Med Inform Assoc
December 2024
Department of Radiology, Stanford University, Stanford, CA 94304, United States.
Objective: Brief hospital course (BHC) summaries are clinical documents that summarize a patient's hospital stay. While large language models (LLMs) depict remarkable capabilities in automating real-world tasks, their capabilities for healthcare applications such as synthesizing BHCs from clinical notes have not been shown. We introduce a novel preprocessed dataset, the MIMIC-IV-BHC, encapsulating clinical note and BHC pairs to adapt LLMs for BHC synthesis.
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