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A Rat's Progress: Plague and the "Migratory Rat" in British India, 1896-1899.
J Hist Med Allied Sci
December 2024
University of St Andrews, Scotland, UK.
Whether referring to oceanic travel on board of ships or to movement in terra firma, framings of the "migratory rat" formed a key epidemiological component of approaches to the Third Plague Pandemic (1894-1959) as the first pandemic to be understood as caused by a zoonotic disease. In this article, I examine the emergence and development of scientific framings of the migratory rat in the first, explosive years of the third plague pandemic in India (1896-1899). Examining publications and archival sources, I ask how this animal figure came to inform and transform epidemiological reasoning.
View Article and Find Full Text PDFPrediction Model for Polyneuropathy in Recent-Onset Diabetes Based on Serum Neurofilament Light Chain, Fibroblast Growth Factor-19 and Standard Anthropometric and Clinical Variables.
Diabetes Metab Res Rev
November 2024
Institute for Clinical Diabetology, German Diabetes Center (Deutsches Diabetes-Zentrum/DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Background: Diabetic sensorimotor polyneuropathy (DSPN) is often asymptomatic and remains undiagnosed. The ability of clinical and anthropometric variables to identify individuals likely to have DSPN might be limited. Here, we aimed to integrate protein biomarkers for reliably predicting present DSPN.
View Article and Find Full Text PDF"Terra firma-forme dermatosis" on the proximal nail fold.
J Eur Acad Dermatol Venereol
November 2024
Department of Dermatology, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, Bruxelles, Belgium.
miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice.
bioRxiv
October 2024
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Massachusetts, 02115, USA.
Article Synopsis
- Liver disease, including hepatocellular carcinoma (HCC), is a serious global issue causing around 2 million deaths per year, with limited effective treatments available.
- This study explores the role of microRNA-21-5p (miR-21) in liver disease progression related to high-fat diets, showing that lower miR-21 levels are linked to worsening conditions in mice, while its absence leads to severe metabolic issues.
- The research suggests that enhancing miR-21 could improve liver health and mitigate the development of cancer in response to high-fat diets, indicating its potential as a therapeutic target.
IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.
J Neuroinflammation
August 2024
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA.
The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, and inflammasome activation. Moreover, expression of a constitutively active IRF3 (S388D/S390D: IRF3-2D) in microglia induces a transcriptional program reminiscent of the Activated Response Microglia and the expression of genes associated with Alzheimer's disease, notably apolipoprotein-e.
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