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Free-Breathing Respiratory Triggered High-Pitch Lung CT: Insights From Phantom and Patient Scans.
Invest Radiol
January 2025
From the Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (A. Schwarz, A. Simon, A.M.); Siemens Healthineers AG, Forchheim, Germany (A. Schwarz, C.H., J.D., A. Simon); Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany (F.K.W., S.G., M.S.); and Institut for Radiology, Pediatric and Neuroradiology, Helios Hospital, Schwerin, Germany (H.-J.R.).
Objective: Respiratory motion can affect image quality and thus affect the diagnostic accuracy of CT images by masking or mimicking relevant lung pathologies. CT examinations are often performed during deep inspiration and breath-hold to achieve optimal image quality. However, this can be challenging for certain patient groups, such as children, the elderly, or sedated patients.
View Article and Find Full Text PDFNeurofeedback and attention modulate somatosensory alpha oscillations but not pain perception.
PLoS Biol
January 2025
Department of Neurology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Pain is closely linked to alpha oscillations (8 < 13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing. Consequently, alpha oscillations might also shape the cerebral processing of nociceptive input and eventually the perception of pain. To test this mechanistic hypothesis, we designed a sham-controlled and double-blind electroencephalography (EEG)-based neurofeedback study.
View Article and Find Full Text PDFPostural instability and gait disturbance are associated with abnormal stereopsis in Parkinson's disease.
PLoS One
January 2025
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Background: Visual dysfunction, including abnormal stereopsis, is a significant non-motor symptom in Parkinson's disease (PD) that can reduce quality of life and appears early in the disease. Abnormal stereopsis is associated with worsening of bradykinesia and freezing of gait, though the exact pathways linking stereopsis to motor symptoms remain unclear. Furthermore, in PD patients, the pedunculopontine nucleus and laterodorsal tegmental complex play an active role in sensorimotor control, and these areas provide cholinergic projections.
View Article and Find Full Text PDFAdvanced low-power filter architecture for biomedical signals with adaptive tuning.
PLoS One
January 2025
Computer Engineering, CCSIT, King Faisal University, Al Hufuf, Kingdom of Saudi Arabia.
This paper presents a low-power, second-order composite source-follower-based filter architecture optimized for biomedical signal processing, particularly ECG and EEG applications. Source-follower-based filters are recommended in the literature for high-frequency applications due to their lower power consumption when compared to filters with alternative topologies. However, they are not suitable for biomedical applications requiring low cutoff frequencies as they are designed to operate in the saturation region.
View Article and Find Full Text PDFzIncubascope: Long-term quantitative imaging of multi-cellular assemblies inside an incubator.
PLoS One
January 2025
LP2N, Laboratoire Photonique Numérique et Nanosciences, University Bordeaux, Talence, France.
Recent advances in bioengineering have made it possible to develop increasingly complex biological systems to recapitulate organ functions as closely as possible in vitro. Monitoring the assembly and growth of multi-cellular aggregates, micro-tissues or organoids and extracting quantitative information is a crucial but challenging task required to decipher the underlying morphogenetic mechanisms. We present here an imaging platform designed to be accommodated inside an incubator which provides high-throughput monitoring of cell assemblies over days and weeks.
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