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A Prospective, Observational, Open-Label, Non-comparative, Multi-center Study for the Evaluation of Efficacy and Safety of Levonadifloxacin (Intravenous and Oral) in Patients With Community-Acquired Bacterial Pneumonia.
Cureus
December 2024
Respiratory Medicine, Gujarat Medical Education and Research Society of Department of Health and Family Welfare (GMERS) Medical College and General Hospital, Vadodara, IND.
Background Community-acquired bacterial pneumonia (CABP) is associated with a substantial healthcare burden. The emergence of multi-drug resistance in is becoming an increasing concern in the management of CABP. This study aims to evaluate the efficacy and safety of levonadifloxacin in the treatment of CABP, focusing on both oral and intravenous (IV) therapy.
View Article and Find Full Text PDFJapan's Growing Public Health Crisis: Tackling the Alarming Increase in Streptococcal Toxic Shock Syndrome.
Cureus
December 2024
Gastroenterology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, IND.
Japan is experiencing a dramatic spike in streptococcal toxic shock syndrome (STSS) cases, exceeding the previous year's statistics. This life-threatening illness, caused by , has been connected not only to the relaxation of COVID-19 precautions but also to the prolonged effects of confinement and lack of contact with the surrounding environment/ecology. The condition is characterized by a sudden onset of symptoms, including high fever, rash, and shock, and demands immediate medical intervention.
View Article and Find Full Text PDFEcthyma amidst the global monkeypox outbreak: A key differential? -A case series.
IDCases
December 2024
Department of Medicine, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Background: Ecthyma is a deeper form of impetigo involving the epidermis and dermis causing ulcerative plaques. Pathogens commonly responsible for the disease (group A beta-hemolytic streptococcus and Staphylococcus aureus) typically afflicts children, presenting during early stages with skin lesions that can closely resemble other vesicular and ulcerative dermatoses, such as those observed in mpox infection. The ongoing global outbreak of monkeypox has escalated the urgency for clinicians to accurately differentiate between these conditions due to their overlapping dermatological manifestations.
View Article and Find Full Text PDF[Rapid Diagnosis of Central Nervous System Infections by Multiplex PCR Assay and the Viral Etiology in Children].
Mikrobiyol Bul
October 2024
University of Health Sciences, Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital, Clinic of Pediatric Infectious Diseases, İzmir, Türkiye.
Article Synopsis
- The study investigates the effectiveness of syndromic tests for diagnosing central nervous system (CNS) infections in children, highlighting the urgency of timely diagnosis.
- A total of 145 pediatric patients were analyzed, revealing that viral pathogens were the most common cause of CNS infections among those tested, with bacterial and no fungal infections detected.
- The use of syndromic tests significantly reduced diagnostic turnaround time, which averaged around 2 hours, and aided in guiding appropriate treatment for affected children.
Endocarditis Mimicking ANCA-Associated Vasculitis.
JACC Case Rep
November 2024
Internal Medicine, Ascension Saint John Hospital, Detroit, Michigan, USA.
Bacterial endocarditis presents as inflammation of the endocardium and valves of the 4 layers of the heart. The presentation and sequelae of bacterial endocarditis may vary and in certain circumstances may mimic rheumatologic disease. Antinuclear cytoplasmic antibody (ANCA)-positive bacterial endocarditis constitutes a special subgroup of bacterial endocarditis.
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