AI Article Synopsis
- Cells are individually encapsulated in tough, thin shells, mimicking bacterial endospores to enhance their survival in harsh environments.
- The 'artificial spores' created allow for control over cell behaviors like division and stress resistance, making them valuable for applications in sensors, therapy, and studying cellular interactions.
- The text explores chemical methods for encapsulating single cells and discusses the current status and future directions of this innovative research area.
Article Abstract
Cells are encapsulated individually within thin and tough shells in a cytocompatible way, by mimicking the structure of bacterial endospores that survive under hostile conditions. The 3D 'cell-in-shell' structures-coined as 'artificial spores'-enable modulation and control over cellular metabolism, such as control of cell division, resistance to external stresses, and surface-functionalizability, providing a useful platform for applications, including cell-based sensors, cell therapy, regenerative medicine, as well as for fundamental studies on cellular metabolism at the single-cell level and cell-to-cell communications. This Concept focuses on chemical approaches to single-cell encapsulation with artificial shells for creating artificial spores, including cross-linked layer-by-layer assembly, bioinspired mineralization, and mussel-inspired polymerization. The current status and future prospects of this emerging field are also discussed.
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| http://dx.doi.org/10.1002/smll.201202174 | DOI Listing |
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