We developed a facile synthesis to yield orthogonally protected mannose building blocks with high overall yields. The protection/glycosylation steps can be carried out in a successive manner without purification of intermediate products. This developed synthesis led to formation of linear/branched tri-, penta- and heptasaccharides.
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http://dx.doi.org/10.1039/c2cc37099a | DOI Listing |
J Org Chem
January 2025
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States.
A scalable, seven step synthesis is reported for a trifluoromethyl toluene protected sulfonated phenylalanine building block whose utility was demonstrated in the synthesis of four CXCR4-derived sulfonopeptides. When compared to a conventional trichloroethyl protected building block, overall yield was improved by up to 4-fold. We believe this building block will prove to be of significant value for the synthesis of a variety of peptide targets containing phenylalanine sulfonate, a bioisostere of tyrosine sulfate, enabling orthogonal protection strategies and improving synthetic efficiency and yield.
View Article and Find Full Text PDFMolecules
January 2025
Engineering Research Center for Hemp and Product in Cold Region of Ministry of Education, Qiqihar University, Qiqihar 161006, China.
At present, the use of conventional reactive dyes on banana-fiber fabric leads to the problem of excessive salt consumption, which is not conducive to environmental protection. In this experimental study, rare-earth-pretreated banana-fiber fabric was dyed with the reactive dye Argazol Navy Blue. The rare-earth pretreatment was carried out to reduce the level of salt consumption, improve dyeing and fixation rates, and reduce the treatment burden of printing and dyeing wastewater.
View Article and Find Full Text PDFSci Rep
January 2025
School of Emergency and Management, Changchun Institute of Technology, No. 3066 Tongzhi Street, Changchun, 130021, Jilin, China.
Improving water retention, erosion resistance and nutrients in desert areas is essential for ecological sustainability. This study evaluated the effects of biochar, polyethylene oxide (PEO), and seaweed fertilizer on the properties of desert sandy soil, focusing on water retention, erosion resistance, and soil nutrients. The sandy soil used in the study was taken from the Tengger Desert in Gansu, China, and an orthogonal experimental design was used to select three different proportions of biochar, PEO, and seaweed fertilizer.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Georgia State University, Chemistry, 50 Decatur ST SE, 30303, Atlanta, UNITED STATES OF AMERICA.
Poly-N-acetyllactosamine (poly-LacNAc) is ubiquitously expressed on cell surface glycoconjugates, serving as the backbone of complex glycans and an extended scaffold that presents diverse glycan epitopes. The branching of poly-LacNAc, where internal galactose (Gal) residues have β1-6 linked N-acetylglucosamine (GlcNAc) attached, forms the blood group I-antigen, which is closely associated with various physiological and pathological processes including cancer progression. However, the underlying mechanisms remain unclear as many of the I-antigen sequences are undefined and inaccessible.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: Hyperuricemia (HUA) is a condition characterized by excessive uric acid production and/or inadequate uric acid excretion due to abnormal purine metabolism in the human body. Uric acid deposits resulting from HUA can lead to complications such as renal damage. Currently, drugs used to treat HUA lack specificity and often come with specific toxic side effects.
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