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A 2D cell segmentation protocol for monitoring multiple STAT signaling pathways by fluorescence microscopy.
STAR Protoc
January 2025
Gill Institute for Neuroscience, Program in Neuroscience, Department of Psychological and Brain Sciences Indiana University, Bloomington, IN 47405, USA. Electronic address:
Microscopic cell segmentation typically requires complex imaging, staining, and computational steps to achieve acceptable consistency. Here, we describe a protocol for the high-fidelity segmentation of the nucleus and cytoplasm in cell culture and apply it to monitor interferon-induced signal transducer and activator of transcription (STAT) signaling. We provide guidelines for sample preparation, image acquisition, and segmentation.
View Article and Find Full Text PDFWorking effectively with individuals with substance use disorders: a qualitative descriptive study.
Br J Nurs
January 2025
Director, Practice Innovation, Standards and Measurement, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Background: Irrespective of where nurses work, they may provide care to individuals with substance use disorders. Unfortunately, some nurses may not understand how to work with these individuals and stigmatisation may occur.
Aim: To explore how to provide effective care for these individuals.
Immunotherapy in Oncogene-Addicted NSCLC: Evidence and Therapeutic Approaches.
Int J Mol Sci
January 2025
Department of Medical Oncology, CRO di Aviano, National Cancer Institute, IRCCS, 33081 Aviano, Italy.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. The discovery of specific driver mutations has revolutionized the treatment landscape of oncogene-addicted NSCLC through targeted therapies, significantly improving patient outcomes. However, immune checkpoint inhibitors (ICIs) have demonstrated limited effectiveness in this context.
View Article and Find Full Text PDFContextual cues facilitate dynamic value encoding in the mesolimbic dopamine system.
Curr Biol
January 2025
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:
Adaptive behavior in a dynamic environmental context often requires rapid revaluation of stimuli that deviates from well-learned associations. The divergence between stable value-encoding and appropriate behavioral output remains a critical component of theories of dopamine's function in learning, motivation, and motor control. Yet, how dopamine neurons are involved in the revaluation of cues when the world changes, to alter our behavior, remains unclear.
View Article and Find Full Text PDFExternal delay and dispersion correction of automatically sampled arterial blood with dual flow rates.
Biomed Phys Eng Express
January 2025
Brain Health Imaging Centre, Centre for Addiction and Mental Health, B68-250 College St, Toronto, Ontario, M5T 1R8, CANADA.
Objective: Arterial sampling for PET imaging often involves continuously measuring the radiotracer activity concentration in blood using an automatic blood sampling system (ABSS). We proposed and validated an external delay and dispersion correction procedure needed when a change in flow rate occurs during data acquisition. We also measured the external dispersion constant of [11C]CURB, [18F]FDG, [18F]FEPPA, and [18F]SynVesT-1.
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