AI Article Synopsis
- The study investigated the water-solubility of two potent V-ATPase inhibitors, archazolid A and archazolid C, using various cosolvents, and found that they had very low solubilities.
- A new water-soluble analogue of these inhibitors was then designed and synthesized.
- The new analogue was tested for its effectiveness in inhibiting V-ATPase activity in a laboratory setting (in vitro).
Article Abstract
The water-solubility of the highly potent V-ATPase inhibitors archazolid A and the glucosylated derivative archazolid C was studied in the presence of a wide range of cosolvents, revealing very low solubilites. The first water-soluble analogue was then designed, synthesized, and evaluated for V-ATPase inhibitory activity in vitro.
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| http://dx.doi.org/10.1016/j.bmcl.2012.09.081 | DOI Listing |
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