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Bevacizumab for Vestibular Schwannomas in Neurofibromatosis Type 2: A Systematic Review of Tumor Control and Hearing Preservation.
J Clin Med
December 2024
Département de Neurochirurgie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France.
: Vestibular schwannomas (VSs), also called acoustic neuromas, are benign tumors affecting the vestibulocochlear nerve, often leading to hearing loss and balance issues. This condition is particularly challenging in patients with neurofibromatosis type 2 (NF2), where VSs tend to develop bilaterally. Conventional treatments, such as surgery and radiotherapy, although effective, carry risks like hearing loss and nerve damage.
View Article and Find Full Text PDFLeptomeningeal Disease Secondary to Invasive Ductal Carcinoma of the Breast: A Rapidly Progressive and Fatal Complication.
Cureus
November 2024
Internal Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, GBR.
Leptomeningeal disease (LMD) is a rare yet serious complication of advanced malignancy, often seen in breast cancer and associated with a poor prognosis. This case report highlights the rapid progression and diagnostic challenges encountered in a woman in her 40s with advanced breast cancer who presented with severe headaches, absence seizures, and diplopia. The patient's complex past history included invasive ductal carcinoma, prior brain metastasis, and recent craniotomy, which added significant challenges to diagnosis and management.
View Article and Find Full Text PDFPhenotyping vestibulocochlear manifestations in Susac syndrome: a cohort study.
Eur Arch Otorhinolaryngol
October 2024
Department of Otorhinolaryngology, Department of Head and Skin, Ghent University Hospital, Ghent, Belgium.
Article Synopsis
- The study aims to understand how the vestibulocochlear system is affected in patients with Susac syndrome (SuS), which is a rare condition that impacts the brain, eyes, and inner ear.
- A review of 21 patient files shows that most experienced various audiovestibular symptoms, including vertigo and sensorineural hearing loss, with specific audiological and vestibular testing revealing common patterns of dysfunction.
- The findings suggest that early treatment with immunosuppressive therapy can help prevent severe audiovestibular problems, indicating the need for more research to understand the underlying causes and improve patient outcomes.
Objective Determination of Site-of-Lesion in Auditory Neuropathy.
Ear Hear
September 2024
Department of Audiology and Speech Pathology, The University of Melbourne, Parkville, Melbourne, Australia.
Article Synopsis
- It involves a case-control design with 10 individuals affected by AN, 7 with neurofibromatosis type 1 (NF1), and 37 control participants, comparing white matter fiber density across different auditory pathways.
- Results show that the presence and pattern of white matter abnormalities differ based on the underlying cause of AN, and these abnormalities have correlations with certain auditory functional measures like speech perception in noise.
Atypical Choroid Plexus Tumor of the Cauda Equina With Metastases to the Spinal Cord and Brain.
Cureus
July 2024
Neuropathology, University of Virginia School of Medicine, Charlottesville, USA.
Article Synopsis
- - A 57-year-old man was diagnosed with a tumor located in the cauda equina, which had metastasized to both the spinal cord and intracranial areas, causing severe lower back pain and balance issues.
- - Imaging revealed a large mass affecting the lumbosacral region, along with intradural and intracranial metastases, prompting further investigation of its pathology.
- - Although the tumor's features initially suggested a choroid plexus tumor, additional tests, including methylation profiling, confirmed the diagnosis as a choroid plexus papilloma, highlighting its unusual location and metastatic behavior.
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