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Adaptive Cost-Benefit Control Fueled by Striatal Dopamine.
Annu Rev Neurosci
January 2025
Department of Cognitive and Psychological Sciences and Carney Institute for Brain Science, Brown University, Providence, Rhode Island, USA; email:
The twenty-first century has brought forth a deluge of theories and data shedding light on the neural mechanisms of motivated behavior. Much of this progress has focused on dopaminergic dynamics, including their signaling properties (how do they vary with expectations and outcomes?) and their downstream impacts in target regions (how do they affect learning and behavior?). In parallel, the basal ganglia have been elevated from their original implication in motoric function to a canonical circuit facilitating the initiation, invigoration, and selection of actions across levels of abstraction, from motor to cognitive operations.
View Article and Find Full Text PDFBuilding a Digital Health Research Platform to Enable Recruitment, Enrollment, Data Collection, and Follow-Up for a Highly Diverse Longitudinal US Cohort of 1 Million People in the All of Us Research Program: Design and Implementation Study.
J Med Internet Res
January 2025
Vibrent Health, Inc, Fairfax, VA, United States.
Background: Longitudinal cohort studies have traditionally relied on clinic-based recruitment models, which limit cohort diversity and the generalizability of research outcomes. Digital research platforms can be used to increase participant access, improve study engagement, streamline data collection, and increase data quality; however, the efficacy and sustainability of digitally enabled studies rely heavily on the design, implementation, and management of the digital platform being used.
Objective: We sought to design and build a secure, privacy-preserving, validated, participant-centric digital health research platform (DHRP) to recruit and enroll participants, collect multimodal data, and engage participants from diverse backgrounds in the National Institutes of Health's (NIH) All of Us Research Program (AOU).
Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults.
Neurology
February 2025
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Background And Objectives: Previous studies have shown inconsistent associations between red meat intake and cognitive health. Our objective was to examine the association between red meat intake and multiple cognitive outcomes.
Methods: In this prospective cohort study, we included participants free of dementia at baseline from 2 nationwide cohort studies in the United States: the Nurses' Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS).
[The emancipatory perspective of health literacy in Brazil: contributions from the Freirean thought to knowledge translation regarding a global concept].
Cad Saude Publica
January 2025
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
This article seeks to reveal the potential for applying key principles of Freirean pedagogy for the effective translation of knowledge and practices associated with the concept of health literacy followed worldwide, based on a critical and emancipatory perspective. It starts from the observation that the process of adopting the concept in Brazil has been more utilitarian than critical, with initiatives predominantly focused on the translation and use of instruments to assess health literacy among population groups. In doing so, this approach has overlooked the academic contributions, practical actors, and social movements in various regions of the country, regarding the application of principles and values of Paulo Freire's thought for the emancipatory promotion of health for individuals and population groups.
View Article and Find Full Text PDFWheat and barley serve as significant nutrient-rich staples that are extensively grown on a global scale, spanning over 219 million hectares. The annual combined global yield is 760.9 million tons, with Kazakhstan contributing 14.
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