AI Article Synopsis
- The study focused on agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17, particularly those with the P301L MAPT mutation.
- Two sibling pairs with FTDP-17 were observed over time to identify the nature of their writing difficulties related to their cognitive and language abilities.
- Results indicated that all patients exhibited dysexecutive agraphia, with additional variations like spatial and aphasic agraphia noted in some siblings, showcasing the diversity of agraphia in this condition.
Article Abstract
Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.
Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.
Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.
Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710298 | PMC |
| http://dx.doi.org/10.1080/13554794.2012.732087 | DOI Listing |
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