A 75-year-old man presented with nasal obstruction, purulent nasal discharge, crusting and a reddish ulcerated swelling over nose and upper lip. There was external nasal deformity. Histology of the lesions showed necrotic granulomatous vasculitis. There was no other systemic involvement. ANCA test was negative. The patient responded well to prednisolone and cyclophosphamide.
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http://dx.doi.org/10.1007/s12070-008-0024-y | DOI Listing |
Cureus
October 2024
Internal Medicine, Unidade Local de Saude do Alto Minho, Viana do Castelo, PRT.
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a rare autoimmune disorder characterized by necrotizing vasculitis affecting small to medium-sized vessels. This condition most commonly affects the lungs, kidneys, and upper respiratory tract. Early recognition and treatment are critical to prevent severe complications and improve prognosis.
View Article and Find Full Text PDFCureus
May 2024
Internal Medicine, University of Minnesota, Minneapolis, USA.
Radiol Case Rep
August 2024
National institute of oncology, University Mohammed V of Rabat, Rabat, Morocco.
Sarcoidosis, a multifaceted granulomatous disease primarily affecting the lungs, occasionally presents in atypical locations. Lacrimal gland involvement, though rare, poses distinct diagnostic challenges. This case report details a 52-year-old female with bilateral lacrimal gland swelling initially suggestive of metastatic tumor due to a history of breast cancer.
View Article and Find Full Text PDFCureus
March 2024
Department of Internal Medicine, Division of Nephrology, Southern Illinois University School of Medicine, Springfield, USA.
Granulomatosis with polyangiitis (GPA) is a rare vasculitis that can pose a significant mortality risk given its multiorgan involvement and is the most common of the three anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. Cardinal pathological features include necrotizing granulomas of the respiratory tract, small and medium vessel vasculitis, and glomerulonephritis. Early treatment is imperative to reduce permanent organ damage such as end-stage kidney disease.
View Article and Find Full Text PDFDiagnostics (Basel)
March 2024
Rheumatology Unit, Department of Medicine DIMED, University of Padua, 35121 Padua, Italy.
Background: Granulomatosis with polyangiitis (GPA) is characterised by granulomatous inflammation and small-to-medium vessel necrotising vasculitis, mainly affecting respiratory tract and kidneys. Renal involvement presenting as tumour-like lesions poses diagnostic and treatment challenges.
Methods: Following the observation of a GPA patient presenting with multiple renal tumour-like lesions, we conducted a systematic literature review on MEDLINE/PubMed, EMBASE, and Cochrane databases.
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