Wegener's granuloma - a case report.

Indian J Otolaryngol Head Neck Surg

ENT Department, Medical College and Hospital, Kolkata, India ; ENT Department, NRS Medical College, Kolkata, India ; Flat 101B, Girikunj, 390, S.N.Roy Road, Kolkata, 700 038 India.

Published: March 2008

A 75-year-old man presented with nasal obstruction, purulent nasal discharge, crusting and a reddish ulcerated swelling over nose and upper lip. There was external nasal deformity. Histology of the lesions showed necrotic granulomatous vasculitis. There was no other systemic involvement. ANCA test was negative. The patient responded well to prednisolone and cyclophosphamide.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3450712PMC
http://dx.doi.org/10.1007/s12070-008-0024-yDOI Listing

Publication Analysis

Top Keywords

wegener's granuloma
4
granuloma case
4
case report
4
report 75-year-old
4
75-year-old man
4
man presented
4
presented nasal
4
nasal obstruction
4
obstruction purulent
4
purulent nasal
4

Similar Publications

Granulomatosis With Polyangiitis Misdiagnosed as Tuberculosis: A Case Report.

Cureus

October 2024

Internal Medicine, Unidade Local de Saude do Alto Minho, Viana do Castelo, PRT.

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a rare autoimmune disorder characterized by necrotizing vasculitis affecting small to medium-sized vessels. This condition most commonly affects the lungs, kidneys, and upper respiratory tract. Early recognition and treatment are critical to prevent severe complications and improve prognosis.

View Article and Find Full Text PDF
Article Synopsis
  • Granulomatosis with polyangiitis (GPA) is a rare type of vasculitis that mainly affects small and medium blood vessels, characterized by granulomas particularly in the upper respiratory tract and kidneys.
  • A 54-year-old woman presented with symptoms leading to the discovery of GPA, despite being seronegative for common antibodies like ANCA; her lung lesions were identified through imaging and biopsy.
  • The patient underwent treatment with intravenous rituximab for six months after diagnoses, which revealed necrotizing granulomatous inflammation.
View Article and Find Full Text PDF

Sarcoidosis, a multifaceted granulomatous disease primarily affecting the lungs, occasionally presents in atypical locations. Lacrimal gland involvement, though rare, poses distinct diagnostic challenges. This case report details a 52-year-old female with bilateral lacrimal gland swelling initially suggestive of metastatic tumor due to a history of breast cancer.

View Article and Find Full Text PDF

Granulomatosis with polyangiitis (GPA) is a rare vasculitis that can pose a significant mortality risk given its multiorgan involvement and is the most common of the three anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. Cardinal pathological features include necrotizing granulomas of the respiratory tract, small and medium vessel vasculitis, and glomerulonephritis. Early treatment is imperative to reduce permanent organ damage such as end-stage kidney disease.

View Article and Find Full Text PDF

Background: Granulomatosis with polyangiitis (GPA) is characterised by granulomatous inflammation and small-to-medium vessel necrotising vasculitis, mainly affecting respiratory tract and kidneys. Renal involvement presenting as tumour-like lesions poses diagnostic and treatment challenges.

Methods: Following the observation of a GPA patient presenting with multiple renal tumour-like lesions, we conducted a systematic literature review on MEDLINE/PubMed, EMBASE, and Cochrane databases.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!