Moebius syndrome (moebius sequence).

Indian J Otolaryngol Head Neck Surg

Department ofENTand Head and Neck Surgery, Government Medical College and Sir Sayaji General Hospital, Gujarat, Vadodara.

Published: October 1999

AI Article Synopsis

  • Moebius Syndrome is a rare disorder characterized by congenital bilateral facial palsy and involvement of several cranial nerves, leading to a masklike, expressionless face.
  • The exact cause of Moebius Syndrome is unknown, and it occurs sporadically.
  • The report discusses a specific case of Moebius Sequence presented to the ENT and Head and Neck Surgery department in Baroda.

Article Abstract

Moebius Syndrome is one of the rare disorder amongst the oromandibular limb hypogenesis. It is of a unknown atiology with sporadic occurrence in which there is congenital bilateral facial palsy,-bilateral involvement of abducent nerve along with other cranial nerves like III, V, IX, X, Xllth and the patient having masklike expressionless face. We are reporting a case of Moebius Sequence who presented to us in the department of ENT and Head and Neck Surgery, Baroda.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451387PMC
http://dx.doi.org/10.1007/BF03022714DOI Listing

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Moebius syndrome (MBS) is a rare congenital disorder characterized by non-progressive facial palsy and ocular abduction paralysis. Most cases are sporadic, but also rare familial cases with autosomal dominant transmission and incomplete penetrance/variable expressivity have been described. The genetic etiology of MBS is still unclear: de novo pathogenic variants in and are reported in only a minority of cases, suggesting the involvement of additional causative genes.

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