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Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis.
J Ethnopharmacol
January 2025
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China. Electronic address:
Ethnopharmacological Relevance: Changyanning tablets (CYN) are a marketed traditional Chinese medicine composed of Diijincao (Euphorbia humifusa Willd.), Jinmaoercao (Hedyotis chrysotricha (Palib.) Merr.
View Article and Find Full Text PDFMorbidity Risk of Infectious Gastroenteritis Attributable to Cold and Heat Temperatures: An Analysis of National Surveillance Data in Japan (2000-2019).
Cureus
December 2024
Epidemiology and Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JPN.
Introduction Climate change is a decisive factor affecting human health. While many epidemiological studies have investigated the acute impacts of ambient temperature on mortality and morbidity, the global burden of infectious gastroenteritis linked to temperature changes remains largely unexplored. Therefore, we aimed to examine the exposure-response associations between ambient temperature and infectious gastroenteritis incidence throughout Japan and quantify the temperature-related morbidity burden.
View Article and Find Full Text PDFEight Years of Norovirus Surveillance in Urban Wastewater: Insights from Next-Generation.
Viruses
January 2025
National Center for Water Safety (CeNSia), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Human noroviruses (HNoVs) are a leading cause of acute gastroenteritis worldwide, with significant public health implications. In this study, wastewater-based epidemiology (WBE) was used to monitor the circulation and genetic diversity of HNoVs in Rome over an eight-year period (2017-2024). A total of 337 wastewater samples were analyzed using RT-nested PCR and next-generation sequencing (NGS) to identify genogroups GI and GII and their respective genotypes.
View Article and Find Full Text PDFPrevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017-2022.
Viruses
January 2025
Laboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, Brazil.
Acute gastroenteritis (AG) is a major illness in early childhood. Recent studies suggest a potential association between human bocavirus (HBoV) and AG. HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family.
View Article and Find Full Text PDFInterrelationships of the Intestinal Microbiome, Trimethylamine N-Oxide and Lipopolysaccharide-Binding Protein with Crohn's Disease Activity.
Pathogens
December 2024
Gastroenterology Department, Regional Clinical Hospital, Karaganda 100000, Kazakhstan.
Unlabelled: Crohn's disease (CD) is a multifactorial inflammatory bowel disease whose pathogenetic mechanisms are a field of ongoing study. Changes in the intestinal microbiome in CD may influence metabolite production and reflect the disease's severity. We investigate the relationship between trimethylamine N-oxide (TMAO) and lipopolysaccharide-binding protein (LPS) levels and changes in the gut microbiome in patients with CD of various degrees of activity.
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