Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The multipotentiality of TRIF-mediated immune machinery may direct the fate of our continuous battle with microbes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537922 | PMC |
| http://dx.doi.org/10.1016/j.micinf.2012.10.011 | DOI Listing |
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