The first total synthesis of aeruginosin 98B was accomplished. The key step is a highly diastereoselective Pd-catalyzed intramolecular asymmetric allylic alkylation reaction of a diastereomeric mixture of allylic carbonates that is enabled by the use of racemic phosphine ligand L1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551629 | PMC |
| http://dx.doi.org/10.1021/ja309947n | DOI Listing |
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