Osteoarthritis is a pathology which forces patients who suffer from it to deal with their illness and to endure it by living differently. The nurse therefore plays a major role in supporting these patients in order to help them regain their self-esteem.
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Clinical proof-of-concept results with a novel TRPA1 antagonist (LY3526318) in 3 chronic pain states.
Pain
December 2024
Eli Lilly and Company, Bracknell, United Kingdom.
Transient receptor potential ankyrin 1 (TRPA1) is implicated in physiological and pathological nociceptive signaling, but the clinical benefit of TRPA1 antagonists in chronic pain is not clearly demonstrated. LY3526318 is an oral, potent, and selective novel TRPA1 antagonist. The Chronic Pain Master Protocol was used to evaluate the safety and efficacy of LY3526318 in 3 randomized, placebo-controlled, proof-of-concept studies in knee osteoarthritis pain (OA), chronic low back pain (CLBP), and diabetic peripheral neuropathic pain (DPNP).
View Article and Find Full Text PDFBalance confidence and associated factors among patients with knee osteoarthritis.
J Bodyw Mov Ther
October 2024
North West Anglia NHS Foundation Trust, United Kingdom.
Introduction: Knee osteoarthritis (KOA) is a progressive condition that results in decreased mobility, self-imposed restriction of activity, and impaired functions such as loss of self-efficacy, fear of falling, and balance impairments. This study assessed balance confidence and associated factors among patients with KOA.
Methods: This cross-sectional study involved 115 patients with KOA.
Pain during menopause.
Maturitas
January 2025
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Phoenix, AZ, USA.
Article Synopsis
- - Menopause occurs between ages 45 and 55, marking the end of a woman's reproductive years, and often involves overlooked pain such as musculoskeletal discomfort, headaches, and vulvovaginal pain.
- - The causes of menopausal pain are complex, tied to hormonal changes, psychosocial factors, and genetics, which can worsen perception of pain due to issues like mood disorders and lack of sleep.
- - The article calls for more research to better understand menopausal pain and emphasizes the importance of effective management strategies to improve the wellbeing and quality of life for women during this transition.
Exploring the role of the built environment and psychosocial mediators on knee function in knee osteoarthritis patients in Singapore: a cross-sectional study.
BMJ Open
November 2024
Orthopaedic Surgery, Woodlands Health, Singapore
Objectives: (1) To examine if a more accessible built environment (BE) is significantly associated with better knee function outcomes in knee osteoarthritis (OA) patients. (2) To assess if the relationship between BE and knee function is mediated by fear of movement and self-efficacy.
Design: Cross-sectional study.
Current Use of Patient-Reported Outcome Measures Ignores Functional Demand.
J Am Acad Orthop Surg
December 2024
From the Department of Orthopaedic Surgery, VOICES Health Policy Research Center, Stanford University, Redwood City, CA (Dr. Kamal, Gomez, Chakraborty, Leversedge, Dr. Amanatullah, Dr. Chou, Dr. Gardner, Dr. Hu, Dr. Safran, Dr. Zhuang), and the Department of Orthopaedic Surgery, University of California-San Francisco, San Francisco, CA (Dr. Shapiro).
Article Synopsis
- Patient-reported outcome measures (PROMs) are tools used in orthopaedic surgery to assess important aspects of musculoskeletal function, like pain and disability, but may fail to fully consider patients' specific functional demands.
- A cross-sectional study involving 169 orthopaedic patients examined their demographics, function, functional demands, pain self-efficacy, and depression symptoms to understand these relationships better.
- The study found that higher functional demands linked to better patient-reported physical function even after accounting for factors like pain self-efficacy and age, suggesting functional demands should be included in PROM assessments for more accurate results.
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