Previous studies have shown that the human papillomavirus type 16 (HPV-16) L2 capsid protein plays an essential role in viral infection, in part through its interaction with sorting nexin 17 (SNX17). We now show that this interaction between L2 and SNX17 is conserved across multiple PV types. Furthermore, we demonstrate that SNX17 is essential for infection with all PV types analyzed, indicating an evolutionarily highly conserved virus entry mechanism.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554065 | PMC |
| http://dx.doi.org/10.1128/JVI.01991-12 | DOI Listing |
Publication Analysis
Top Keywords
snx17
4
snx17 facilitates
4
facilitates infection
4
infection diverse
4
diverse papillomavirus
4
papillomavirus types
4
types previous
4
previous studies
4
studies human
4
human papillomavirus
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!