The spatial and temporal control of chromosome duplication and segregation is crucial for proper cell division. While this process is well studied in eukaryotic and some prokaryotic organisms, relatively little is known about it in prokaryotic polyploids such as Synechococcus elongatus PCC 7942, which is known to possess one to eight copies of its single chromosome. Using a fluorescent repressor-operator system, S. elongatus chromosomes and chromosome replication forks were tagged and visualized. We found that chromosomal duplication is asynchronous and that the total number of chromosomes is correlated with cell length. Thus, replication is independent of cell cycle and coupled to cell growth. Replication events occur in a spatially random fashion. However, once assembled, replisomes move in a constrained manner. On the other hand, we found that segregation displays a striking spatial organization in some cells. Chromosomes transiently align along the major axis of the cell and timing of alignment was correlated to cell division. This mechanism likely contributes to the non-random segregation of chromosome copies to daughter cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480399 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047837 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Spatial and temporal analyses of Dermacentor variabilis (Say) (Acari: Ixodidae) in central and eastern Canada.
Med Vet Entomol
January 2025
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Dermacentor variabilis (Say) (Acari: Ixodidae) is a vector for pathogens that can impact human and animal health. The geographic range of this species is expanding, but there are some areas with limited up-to-date information on the distribution of D. variabilis.
View Article and Find Full Text PDFA dataset of forest regrowth in globally key deforestation regions.
Sci Data
January 2025
Key Laboratory of Humid Subtropical Eco-Geographical Process of Ministry of Education, School of Geographical Sciences, Fujian Normal University, Fuzhou, 350117, China.
Deforestation-induced forest loss largely affects both the carbon budget and ecosystem services. Subsequent forest regrowth plays a crucial role in ecosystem restoration and carbon replenishment. However, there is an absence of comprehensive datasets explicitly delineating the forest regrowth following deforestation.
View Article and Find Full Text PDFLong-term reconstructed vegetation index dataset in China from fused MODIS and Landsat data.
Sci Data
January 2025
Institute of Carbon Neutrality, Sino-French Institute for Earth System Science, College of Urban and Environmental Sciences, Peking University, Beijing, 100091, China.
The vegetation index is a key satellite-based variable used to monitor global vegetation distribution and growth. However, existing vegetation index datasets face limitations in achieving both high spatial and temporal resolution, restricting their application potential. This study revised a machine learning spatiotemporal fusion model (InENVI) to produce a high-resolution NDVI dataset with 8-day temporal and 30 m spatial resolution, covering China from 2001 to 2020.
View Article and Find Full Text PDFSleep and circadian rhythms modeling: From hypothalamic regulatory networks to cortical dynamics and behavior.
Handb Clin Neurol
January 2025
School of Physics, Faculty of Science, University of Sydney, Camperdown, NSW, Australia.
Sleep and circadian rhythms are regulated by dynamic physiologic processes that operate across multiple spatial and temporal scales. These include, but are not limited to, genetic oscillators, clearance of waste products from the brain, dynamic interplay among brain regions, and propagation of local dynamics across the cortex. The combination of these processes, modulated by environmental cues, such as light-dark cycles and work schedules, represents a complex multiscale system that regulates sleep-wake cycles and brain dynamics.
View Article and Find Full Text PDFThe moderating and mediating role of the placenta in the association between prenatal exposure to air pollutants and birth weight: A twin study.
Environ Res
January 2025
Department of Epidemiology, NUTRIM School for Translational Research in Metabolism, Maastricht University Medical Centre, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:
Prenatal exposure to air pollution has been linked to lower birth weight, yet the role of the placenta in this association is often overlooked. This study investigates whether placental characteristics act as moderators or mediators in the association between prenatal exposure to particulate matter (PM) and nitrogen dioxide (NO) and birth weight in twins. The study included 3340 twins (born 2002-2013) from the East Flanders Prospective Twin Survey.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!