Local interactions between (bio)chemicals and biological interfaces play an important role in fields ranging from surface patterning to cell toxicology. These interactions can be studied using microfluidic systems that operate in the "open space", that is, without the need for the sealed channels and chambers commonly used in microfluidics. This emerging class of techniques localizes chemical reactions on biological interfaces or specimens without imposing significant "constraints" on samples, such as encapsulation, pre-processing steps, or the need for scaffolds. They therefore provide new opportunities for handling, analyzing, and interacting with biological samples. The motivation for performing localized chemistry is discussed, as are the requirements imposed on localization techniques. Three classes of microfluidic systems operating in the open space, based on microelectrochemistry, multiphase transport, and hydrodynamic flow confinement of liquids are presented.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201201798 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sesterterpenoids: sources, structural diversity, biological activity, and data management.
Nat Prod Rep
January 2025
Department of Pharmacy, University of Genova, Viale Cembrano 4, 16148 Genova, Italy.
Reviewing the literature published up to October 2024.Sesterterpenoids are one of the most chemically diverse and biologically promising subgroup of terpenoids, the largest family of secondary metabolites. The present review article summarizes more than seven decades of studies on isolation and characterization of more than 1600 structurally novel sesterterpenoids, supplemented by biological, pharmacological, ecological, and geographic distribution data.
View Article and Find Full Text PDFIdentification of novel triazolylquinoxaline-based metal complexes supported by experimental and virtual screenings.
Dalton Trans
January 2025
Institute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.
The formation of novel complexes from so far non-investigated ligands and different metal centers is important for the development of new functional materials such as (photo)catalysts or biologically active compounds. Still, promising strategies to quickly and systematically investigate the complexation behavior of selected ligands are rare. We developed an NMR-based screening approach to monitor changes within reaction mixtures containing metals and ligands on a small scale a simple but reliable protocol.
View Article and Find Full Text PDFFunctional hydrogel empowering 3D printing titanium alloys.
Mater Today Bio
February 2025
Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China.
Titanium alloys are widely used in the manufacture of orthopedic prosthesis given their excellent mechanical properties and biocompatibility. However, the primary drawbacks of traditional titanium alloy prosthesis are their much higher elastic modulus than cancellous bone and poor interfacial adhesion, which lead to poor osseointegration. 3D-printed porous titanium alloys can partly address these issues, but their bio-inertness still requires modifications to adapt to different physiological and pathological microenvironments.
View Article and Find Full Text PDFHayai-Annotation: A functional gene prediction tool that integrates orthologs and gene ontology for network analysis in plant species.
Comput Struct Biotechnol J
December 2024
Kazusa DNA Research Institute, Kazusa-Kamatari, 2-6-7, Kisarazu, Chiba 292-0818, Japan.
Hayai-Annotation, an annotation tool powered by the R-shinydashboard browser interface, implements a workflow that integrates sequence alignment using DIAMOND against UniProtKB Plants and ortholog inference using OrthoLoger. We here propose a pipeline to explore genome evolution and adaptation from a different perspective, by creating a network considering orthologs and gene ontology as nodes, with edges based on the annotation for each gene. This approach aims to improve the visualization of conserved biological processes and functions, highlight species-specific adaptations, and enhance the ability to infer the functions of uncharacterized genes by comparing edge patterns across species.
View Article and Find Full Text PDFUnlabelled: Myosin-IC (myo1c) is a class-I myosin that supports transport and remodeling of the plasma membrane and membrane-bound vesicles. Like other members of the myosin family, its biochemical kinetics are altered in response to changes in mechanical loads that resist the power stroke. However, myo1c is unique in that the primary force-sensitive kinetic transition is the isomerization that follows ATP binding, not ADP release as in other slow myosins.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!