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Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion. | LitMetric

AI Article Synopsis

Article Abstract

The advent of nanotechnology has ushered in the use of modified nanoparticles as potential antiviral agents against diseases such as herpes simplex virus 1 and 2 (HSV-1) (HSV-2), human immunodeficiency virus (HIV), monkeypox virus, and hepatitis B virus. Here we describe the application of tin oxide (SnO(2)) nanowires as an effective treatment against HSV-1 infection. SnO(2) nanowires work as a carrier of negatively charged structures that compete with HSV-1 attachment to cell bound heparan sulfate (HS), therefore inhibiting entry and subsequent cell-to-cell spread. This promising new approach can be developed into a novel form of broad-spectrum antiviral therapy especially since HS has been shown to serve as a cellular co-receptor for a number of other viruses as well, including the respiratory syncytial virus, adeno-associated virus type 2, and human papilloma virus.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480479PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048147PLOS

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