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Prenatal vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation. | LitMetric

Prenatal vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation.

Int J Mol Sci

Neurobiology of Cell Interactions and Neurophysiopathology, Centre National de la Recherche Scientifique, UMR 7259, Aix Marseille Université, Marseille 13015, France.

Published: March 2016

AI Article Synopsis

  • In a previous study, offspring of mice with vitamin D deficiency during pregnancy experienced less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE) compared to control mice.
  • In the follow-up, F(2) female mice whose F(1) parents had vitamin D deficiency exhibited an unexpectedly earlier and more severe EAE, challenging initial findings.
  • The researchers then examined data from the REFGENSEP database, noting a potential trend of fewer births in the Fall among parents of MS patients, but additional studies are needed for confirmation.

Article Abstract

In a previous study, we demonstrated that mouse adult F(1) offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. We then wondered whether a similar response was observed in the subsequent generation. To answer this question, we assessed F(2) females whose F(1) parents (males or females) were vitamin D-deprived when developing in the uterus of F(0) females. Unexpectedly, we observed that the vitamin D deficiency affecting the F(0) pregnant mice induced a precocious and more severe EAE in the F(2) generation. This paradoxical finding led us to assess its implications for the epidemiology of Multiple Sclerosis (MS) in humans. Using the REFGENSEP database for MS trios (the patient and his/her parents), we collected the parents' dates of birth and assessed a potential season of birth effect that could potentially be indicative of the vitamin D status of the pregnant grandmothers. A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472720PMC
http://dx.doi.org/10.3390/ijms130910911DOI Listing

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