Objective: Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options.
Methods: We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacological potential and explored the biology of a potential mechanism of action in well-established experimental models.
Results: Amiloride was shown to block cortical spreading depression, the experimental correlate of aura, and inhibited trigeminal activation in in vivo migraine models, via an acid-sensing ion channel 1 mechanism. Remarkably, amiloride then demonstrated good clinical efficacy in a small open-labeled pilot study of patients, reducing aura and headache symptoms in 4 of 7 patients with otherwise intractable aura.
Interpretation: The observations here identify an entirely novel treatment strategy for migraine.
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| http://dx.doi.org/10.1002/ana.23653 | DOI Listing |
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