Objectives: A profound knowledge of physiologic lower limb alignment is essential to understand deformities and to plan surgical correction. The gold standard in radiographic assessment is the long standing radiograph with a forward directed patella. The advantage of computed tomography (CT) is that its cutting-edge image technique can visualize the femur condyles. Study purpose was to determine if the CT-scout view has the potential to replace the standing radiograph.
Materials And Methods: We compared the geometric data obtained from long standing radiograph and CT-scout views both with patella forward position. Furthermore, we developed a method of positioning the lower extremity stable on the CT table, where the femoral condyles became the new orientation criterion. Finally, we evaluated differences in the data ascertainment between the long standing radiograph with patella facing forward and the CT-scout view with the posterior edge of femoral condyles orientated parallel to the radiographic cassette.
Results: The geometric data of long standing radiograph and CT-scout views are comparable if the leg is in the same rotational position. We developed a CT positioning jig to adjust the femur condyles parallel to the radiographic cassette. In 80 % of the cases, the deviation was 5° or less. These scout views showed statistically significant differences when compared with data from standing radiograph with a forward centered patella.
Conclusion: No evidence was found clearly excluding the possibility of an exclusive use of the CT-scout view for the analysis of the leg geometry. However, advantages of the long standing radiograph became obvious.
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http://dx.doi.org/10.1007/s00402-012-1635-z | DOI Listing |
J Am Chem Soc
January 2025
State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China.
A prevalent challenge in particulate photocatalytic water splitting lies in the fact that while numerous photocatalysts exhibit outstanding hydrogen evolution reaction (HER) activity in organic sacrificial reagents, their performance diminishes markedly in a Z-scheme water splitting system using electronic mediators. This underlying reason remains undefined, posing a long-standing issue in photocatalytic water splitting. Herein, we unveiled that the primary reason for the decreased HER activity in electronic mediators is due to the strong adsorption of shuttle ions on cocatalyst surfaces, which inhibits the initial proton reduction and results in a severe backward reaction of the oxidized shuttle ions.
View Article and Find Full Text PDFNat Commun
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Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
The rate at which transcription factors (TFs) bind their cognate sites has long been assumed to be limited by diffusion, and thus independent of binding site sequence. Here, we systematically test this assumption using cell-to-cell variability in gene expression as a window into the in vivo association and dissociation kinetics of the model transcription factor LacI. Using a stochastic model of the relationship between gene expression variability and binding kinetics, we performed single-cell gene expression measurements to infer association and dissociation rates for a set of 35 different LacI binding sites.
View Article and Find Full Text PDFSci Rep
January 2025
Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Barcelona, Spain.
Vaccination stands as one of the most sustainable and promising strategies to control infectious diseases in animal production. Nevertheless, the causes for antibody response variation among individuals are poorly understood. The animal microbiota has been shown to be involved in the correct development and function of the host immunity, including the antibody response.
View Article and Find Full Text PDFCan J Ophthalmol
January 2025
Department of Ophthalmology, Sheba Medical Center of Israel, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Objective: Adults who undergo strabismus surgery, in addition to cosmesis, could benefit from improved stereopsis. This improvement is associated with the performance of motor skill tasks in young adults; they reduce the risk of tripping or falling during everyday locomotion and improve reading efficiency. This study aimed to assess stereopsis level after strabismus surgery in adults who underwent strabismus surgery for any reason.
View Article and Find Full Text PDFJ Arthroplasty
January 2025
Department of Orthopedic Surgery, Nishinomiya Watanabe Hospital, Hyogo, Japan.
Background: Previous clinical studies suggest that preserving the anterior cruciate ligament (ACL) is crucial for stable knee motion and long-term longevity of the reconstructed knee. The ACL damage or loss often occurs in advanced medial osteoarthritis (OA). This study aimed to investigate the correlation between ACL damage and varus deformity progression as a risk factor for ACL tears in knee OA.
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