AI Article Synopsis
- BAG1 is a multifunctional protein that plays a role in reducing cell death (apoptosis) and promoting nerve cell differentiation.
- Researchers studied its expression in rats after a sciatic nerve injury and found that BAG1 levels increased, peaking two weeks post-injury before returning to normal after four weeks.
- The study indicates that BAG1 is mainly found in Schwann cells, which support nerve repair, and its expression is linked to the differentiation process in these cells when stimulated by cAMP.
Article Abstract
Bcl-2-associated athanogene-1 (BAG1), a co-chaperone for Hsp70/Hsc70, is a multifunctional protein, which has been shown to suppress apoptosis and enhance neuronal differentiation. However, the expression and roles of BAG1 in peripheral system lesions and repair are still unknown. In this study, we investigated the dynamic changes in BAG1 expression in an acute sciatic nerve crush model in adult rats. Western blot analysis revealed that BAG1 was expressed in normal sciatic nerves. BAG1 expression increased progressively after sciatic nerve crush, reached a peak 2 weeks post-injury, and then returned to the normal level 4 weeks post-injury. Spatially, we observed that BAG1 was mainly expressed in Schwann cells and that BAG1 expression increased in Schwann cells after injury. In vitro, we found that BAG1 expression increased during the cyclic adenosine monophosphate (cAMP)-induced Schwann cell differentiation process. BAG1-specific siRNA inhibited cAMP-induced Schwann cell differentiation. In conclusion, we speculated that BAG1 was upregulated in the sciatic nerve after crush, which was associated with Schwann cell differentiation.
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| http://dx.doi.org/10.1007/s12031-012-9910-6 | DOI Listing |
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