Rigid Mn(II) chelate as efficient MRI contrast agent for vascular imaging.

Dalton Trans

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, PR China.

Published: December 2012

The aza-semi-crown pentadentate ligand rigidified by pyridine and piperidine rings was designed and synthesized. It can react with Mn(II) in water to form complex with improved longitudinal relaxivity, leading to efficient signal intensity enhancement of vascular vessels under a clinical magnetic resonance imaging scanner.

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Source
http://dx.doi.org/10.1039/c2dt31696jDOI Listing

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