Polarized cell morphogenesis requires actin cytoskeleton rearrangement for polarized transport of proteins, organelles and secretory vesicles, which fundamentally underlies cell differentiation and behavior. During yeast mating, Saccharomyces cerevisiae responds to extracellular pheromone gradients by extending polarized projections, which are likely maintained through vesicle transport to (exocytosis) and from (endocytosis) the membrane. We experimentally demonstrate that the projection morphology is pheromone concentration-dependent, and propose the underlying mechanism through mathematical modeling. The inclusion of membrane flux and dynamically evolving cell boundary into our yeast mating signaling model shows good agreement with experimental measurements, and provides a plausible explanation for pheromone-induced cell morphology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921116 | PMC |
| http://dx.doi.org/10.1016/j.febslet.2012.10.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
PLoS Biol
December 2024
Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Starvation, which is associated with inactivation of the growth-promoting TOR complex 1 (TORC1), is a strong environmental signal for cell differentiation. In the fission yeast Schizosaccharomyces pombe, nitrogen starvation has distinct physiological consequences depending on the presence of mating partners. In their absence, cells enter quiescence, and TORC1 inactivation prolongs their life.
View Article and Find Full Text PDFMolecular epidemiology and distribution of in human immunodeficiency-positive patients in China.
J Int Med Res
December 2024
Department of Dermatology, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Objective: This study aims to inform the prevention and treatment of infections in China by analyzing the molecular epidemiology and distribution patterns of the pathogen.
Methods: A cross-sectional study was conducted involving a retrospective analysis of 64 clinical strains of isolated from January 2018 to April 2023 across various domestic regions. Patient information was collected from human immunodeficiency virus-positive individuals in multiple hospitals located in 19 cities within China's southeastern coastal and southwestern regions.
From Starfish to Gibberellins: Biosynthesis and Regulation of Plant Hormones.
Annu Rev Plant Biol
December 2024
RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan; email:
I grew up with laboratory glassware and microscopes as treasures from a young age. I was a member of the Chemistry Club in junior high school, and when I visited RIKEN with club members, I wished to become an organic chemist in the future. I received my doctoral degree through the study of the spawning inhibitor of starfish.
View Article and Find Full Text PDFCardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways.
World J Cardiol
November 2024
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20810, United States.
Article Synopsis
- Cardiovascular disorders are the leading cause of death worldwide and are closely linked to chronic diseases like nonalcoholic fatty liver disease (NAFLD), which is on the rise alongside diabetes.
- NAFLD can lead to severe complications like cirrhosis, and individuals with metabolic disorders are over twice as likely to suffer from cardiac issues and liver diseases compared to those without.
- The common mechanism between cardiovascular disorders and NAFLD is SIRT1, a protein that affects metabolic pathways and may provide cellular protection, suggesting that understanding SIRT1 could improve treatment options for these diseases.
Wild yeast isolation by middle school students reveals features of populations residing on North American oaks.
G3 (Bethesda)
November 2024
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Article Synopsis
- The budding yeast Saccharomyces cerevisiae's life cycle traits, like stable haploid clones and controllable mating, make it valuable for lab research.
- Research showed that natural isolates have diverse HO alleles, but limited diversity was found in North American oak isolates, indicating broad dispersal.
- A hands-on educational activity enabled students to isolate and identify wild yeast, fostering collaboration among different educational levels and showing adaptability for other regions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!