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| http://dx.doi.org/10.1007/s12291-009-0061-7 | DOI Listing |
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Chronobioethics: Symphony of biological clocks observed by 7-day/24-hour ambulatory blood pressure monitoring and cardiovascular health.
Biomed J
June 2024
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA.
Background: The high prevalence of desynchronized biological rhythms is becoming a primary public health concern. We assess complex and diverse inter-modulations among multi-frequency rhythms present in blood pressure (BP) and heart rate (HR).
Subjects: and Methods: We performed 7-day/24-hour Ambulatory BP Monitoring in 220 (133 women) residents (23 to 74 years) of a rural Japanese town in Kochi Prefecture under everyday life conditions.
Some Near- and Far-Environmental Effects on Human Health and Disease with a Focus on the Cardiovascular System.
Int J Environ Res Public Health
April 2020
Executive Medical Center, Totsuka Royal Clinic, Tokyo Women's Medical University, Tokyo 169-0071, Japan.
Environmental effects on human physiopathology are revisited herein from a chronobiologic viewpoint, with a focus on the cardiovascular system. Physiological variables undergo recurring changes that are predictable in a statistical, albeit not deterministic way. Biological rhythms cover a broad range of frequencies, which are usually shared by the environment as "co-periodisms".
View Article and Find Full Text PDFChronomics of Circulating Plasma Lipid Peroxides and Antioxidant Enzymes in Renal Stone Formers.
Indian J Clin Biochem
April 2019
5Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455 USA.
Article Synopsis
- The study examined how lipid peroxidation and antioxidant defenses vary over a 24-hour period in renal stone patients and healthy volunteers, focusing on their circadian rhythms.
- Both groups were monitored under similar conditions, and blood samples were taken every six hours to measure levels of plasma lipid peroxides (MDA) and antioxidant enzyme activities (SOD, GPx, GR, CAT).
- Results showed that renal stone patients had higher levels of MDA and lower levels of antioxidants compared to healthy subjects, indicating a significant circadian variation that may influence prevention and treatment strategies for kidney stones.
Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
Biogerontology
August 2017
Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.
Article Synopsis
- Aging negatively impacts the circadian timing system in mammals, leading to dysfunction, which has been observed in studies involving aging and Parkinson's disease models.
- Research involving proteomic analysis identified varying expression levels of core clock gene proteins at different times of day in various brain regions of both young and aging rats, highlighting changes associated with age and disease.
- Melatonin administration appears to help modulate the protein profiles linked to circadian rhythms, suggesting its potential as a treatment for circadian dysfunction and promoting better health in aging populations.
Effect of gender, age, diet and smoking status on chronomics of circulating plasma lipid components in healthy Indians.
Clin Chim Acta
August 2016
Halberg Chronobiology Center, University Of Minnesota, Minneapolis, MN 55455, USA. Electronic address:
Background: Circulating lipid components were studied under near-normal tropical conditions (around Lucknow) in 162 healthy volunteers - mostly medical students, staff members and members of their families (103 males and 59 females; 7 to 75y), subdivided into 4 age groups: A (7-20y; N=42), B (21-40y; N=60), C (41-60y; N=35) and D (61-75y; N=25).
Methods: Blood samples were collected from each subject every 6h for 24h (4 samples). Plasma was separated and total cholesterol, high-density-lipoprotein (HDL) cholesterol, phospholipids and total lipids were measured spectrophotometrically.
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