AI Article Synopsis
- The study explores the relationship between C-reactive protein and microalbuminuria in Type 2 Diabetes Mellitus patients, focusing on those with poor and adequate glycemic control.
- In patients with poor glycemic control, a significant positive correlation was found between elevated C-reactive protein levels and the presence of microalbuminuria.
- The findings suggest that inflammation and endothelial dysfunction play a role in microalbuminuria development, highlighting the critical role of maintaining good glycemic control in diabetic patients to manage inflammation.
Article Abstract
Microalbuminuria and C-reactive protein reflect closely related components of the same disease process. The present study attempts to evaluate whether any association exists between C-reactive protein and microalbuminuria in Type 2 Diabetes Mellitus patients with poor and adequate glycemic control. It was observed that in diabetics with poor glycemic control, microalbuminuria showed a significant positive correlation with C-reactive protein and the prevalence of microalbuminuria was significantly more at elevated C-reactive protein levels. These parameters were not significant in subjects with adequately controlled disease. Further, there was a significant increase in levels of microalbuminuria in patients with poor glycemic control when compared to well-controlled diabetics at comparative levels of C-reactive protein. This study supports the hypothesis that endothelial dysfunction and inflammatory activity are involved in the pathogenesis of microalbuminuria and underscores the importance of glycemic control in the progression of inflammation in diabetes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453818 | PMC |
| http://dx.doi.org/10.1007/BF02913314 | DOI Listing |
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