We propose a rapid, simple metodology for routine analysis of human urine to detect vanillylmandelic and homovanillic acid related to neuroblastoma. The assay were specific capillary gas chromatography with flame ionization detection. In this methodology an internal standard is used and the procedure involves ethyl ester formation without isolation of the compounds of interest. The run time is 36 minutes. We also report quantitative results for urinary vanillylmandelic and homovanillic acid in neuroblastoma patients, demonstrating the diagnostic value of this method.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453848 | PMC |
| http://dx.doi.org/10.1007/BF02867423 | DOI Listing |
Publication Analysis
Top Keywords
capillary gas
8
gas chromatography
8
vanillylmandelic homovanillic
8
homovanillic acid
8
acid neuroblastoma
8
urinary catecholamine
4
catecholamine metabolites
4
metabolites capillary
4
chromatography method
4
method experience
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!