AI Article Synopsis
- The study found that both maternal and fetal blood cells show increased signs of oxidative stress during various pregnancy complications, indicated by higher levels of lipid and protein damage.
- Fetuses born after premature rupture of membranes had notably elevated lipid peroxidation, with significant increases in malondialdehyde levels compared to control groups.
- Additionally, mothers who had cesarean deliveries or experienced prolonged labor also exhibited significantly increased oxidative stress markers in their erythrocytes.
Article Abstract
The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01). In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively). In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001 and p<0.05 respectively).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3453866 | PMC |
| http://dx.doi.org/10.1007/BF02867371 | DOI Listing |
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